CASRN: 92665-29-7
Drug Levels and Effects
Summary of Use during Lactation
Limited information indicates that cefprozil produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. Cefprozil is acceptable in nursing mothers.
Drug Levels
Maternal Levels. Nine healthy women were given a single 1 gram dose of cefprozil orally 6 to 12 months postpartum. Milk levels of cis-cefprozil (which accounts for 90% of cefprozil) ranged from 0.7 to 1.3 mg/L during the 12 hours after the dose. The peak level averaged 3.4 mg/L at 6 hours after the dose. By 24 hours after the dose, milk cefprozil levels were 0.3 mg/L.[1,2] Using the peak milk level value and assuming that the trans-isomer adds an additional 10% to the peak, an exclusively breastfed infant would receive a maximum of 3.3% of the weight-adjusted maternal dosage.
Infant Levels. Relevant published information was not found as of the revision date
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Shyu WC, Shah VR, Campbell DA, et al. Excretion of cefprozil into human breast milk. Antimicrob Agents Chemother 1992;36:938-41. [PMC free article: PMC188771] [PubMed: 1510416]
- 2.
- Shyu WC, Shah VR, Venitz J, et al. The excretion of cefprozil (CPR) into breast milk. Clin Pharmacol Ther 1992;51:182. doi:10.1038/clpt.1992.14 [CrossRef]
Substance Identification
Substance Name
Cefprozil
CAS Registry Number
92665-29-7
Drug Class
Breast Feeding
Lactation
Milk, Human
Anti-Infective Agents
Antibacterial Agents
Cephalosporins
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Publication Details
Publication History
Last Revision: October 15, 2024.
Copyright
Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.
Publisher
National Institute of Child Health and Human Development, Bethesda (MD)
NLM Citation
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Cefprozil. [Updated 2024 Oct 15].