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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

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Drugs and Lactation Database (LactMed®) [Internet].

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Last Revision: November 30, 2022.

Estimated reading time: 1 minute

CASRN: 92339-11-2

image 135014397 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Intravenous iodinated contrast media are poorly excreted into breastmilk and poorly absorbed orally so they are not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. One report of very small amounts of iodine from iodixanol in breastmilk supports this generalization. Guidelines developed by several professional organizations state that breastfeeding need not be disrupted after a nursing mother receives an iodine-containing contrast medium.[1-4]

Drug Levels

Maternal Levels. A mother was given 100 mL of iodixanol (containing 320 mg of iodine per mL) intravenously immediately postpartum for diagnosis of severe abdominal pain. She was found to have a hematoma resulting in acute tubular necrosis with a serum creatinine of 2.5 mg/dL (222 micromoles/L). Breastmilk samples taken on days 1 and 4 postpartum contained 55 and 28 mg/L of iodine, respectively. The authors calculated that the infant would receive 0.017% of the total administered maternal dose of iodine on day 1 and 0.05% on day 4 postpartum.[5] However, these values could be somewhat different in a patient with normal kidney function.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Diatrizoate, Iohexol


Webb JA, Thomsen HS, Morcos SK, et al. The use of iodinated and gadolinium contrast media during pregnancy and lactation. Eur Radiol. 2005;15:1234–40. [PubMed: 15609057]
Chen MM, Coakley FV, Kaimal A, et al. Guidelines for computed tomography and magnetic resonance imaging use during pregnancy and lactation. Obstet Gynecol. 2008;112:333–40. [PubMed: 18669732]
Copel J, El-Sayed Y, Heine RP, et al. Committee Opinion No. 723: Guidelines for diagnostic imaging during pregnancy and lactation. Obstet Gynecol. 2017;130:e210–e216. [PubMed: 28937575]
American College of Radiology Committee on Drugs and Contrast Media. Administration of contrast media to breast-feeding mothers. In, ACR manual on contrast media. 2022;Version 2022:106-7. https://www​.acr.org/Clinical-Resources​/Contrast-Manual.
Chruscicki A, Morton AR, Akbari A, et al. Composition of human breast milk in acute kidney injury. Obstet Med. 2017;10:79–82. [PMC free article: PMC5480647] [PubMed: 28680467]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Milk, Human

Contrast Media

Diagnostic Agents

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Copyright Notice

Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Bookshelf ID: NBK501403PMID: 30000463


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