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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

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Drugs and Lactation Database (LactMed®) [Internet].

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Last Revision: February 15, 2021.

Estimated reading time: 1 minute

CASRN: 51-71-8

image 134972595 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Because of the lack of data on use during breastfeeding, other antidepressants are preferred during breastfeeding.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Phenelzine can elevate serum prolactin in some patients and has caused galactorrhea in nonpregnant, nonnursing patients.[1,2] The clinical relevance of these findings in nursing mothers is not known. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Nortriptyline, Paroxetine, Sertraline


Coker F, Taylor D. Antidepressant-induced hyperprolactinaemia: Incidence, mechanisms and management. CNS Drugs. 2010;24:563–74. [PubMed: 20527996]
Segal M, Heys RF. Inappropriate lactation. Br Med J. 1969;4:236. [PMC free article: PMC1629889] [PubMed: 5388733]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Antidepressive Agents

Monoamine Oxidase Inhibitors

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Copyright Notice

Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Bookshelf ID: NBK501172PMID: 30000231


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