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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

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Drugs and Lactation Database (LactMed®) [Internet].

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Last Revision: August 15, 2023.

Estimated reading time: 1 minute

CASRN: 73-48-3

image 134972798 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

No information is available on the amount of bendroflumethiazide in breastmilk. Intense diuresis with large doses of bendroflumethiazide can decrease breastmilk production, especially during the neonatal period. Shorter-acting diuretics in low doses are preferred over bendroflumethiazide.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Bendroflumethiazide has been used to suppress lactation in oral doses of 5 mg twice daily for 5 days, and in doses of 10 mg in the morning and 5 mg in the afternoon.[1,2] The added contribution of the diuretic to these measures, which are effective in suppressing lactation, has not been studied. There are no data on the effects of potent diuretics on established, ongoing lactation.

Alternate Drugs to Consider

Chlorothiazide, Hydrochlorothiazide


Healy M. Suppressing lactation with oral diuretics. Lancet 1961;1:1353-4. doi:10.1016/S0140-6736(61)90289-6 [CrossRef]
Stout G. Suppression of lactation. Br Med J 1962;1:1150. Letter. PMC1958377

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Antihypertensive Agents

Thiazide Diuretics

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Copyright Notice

Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Bookshelf ID: NBK501127PMID: 30000186


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