CASRN: 851199-59-2
Drug Levels and Effects
Summary of Use during Lactation
Linaclotide is minimally absorbed from the gastrointestinal tract and the drug and its active metabolite are not measurable in milk following administration of doses up to 290 mcg daily. Linaclotide appears to be acceptable in nursing mothers and no special precautions are required.
Drug Levels
Linaclotide is metabolized in the gastrointestinal tract to its active metabolite, MM-419447.
Maternal Levels. In a multicenter study, 7 lactating women were taking linaclotide in doses of 72 mcg (n = 5), 145 mcg (n = 1) or 290 mcg (n = 1) once daily. Milk was pumped on day 1 and day 3 of the study. Over 24-hours of milk collection on day 3, concentrations of linaclotide and MM-419447 in milk samples were below the quantitation limits (<0.25 mcg/L and <1 mcg/L, respectively) at all time points in all participants.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
(Irritable Bowel Syndrome) Lubiprostone, Plecanatide, Polyethylene Glycol, Psyllium, Tenapanor
References
- 1.
- Crittenden N, McGeeney D, Assouline-Dayan Y, et al. Linaclotide is not detectable in breast milk of lactating women: An open-label, phase 1 study. J Can Assoc Gastroenterol 2021;4 (Suppl 1):A236. doi:10.1093/jcag/gwab002.234 [CrossRef]
Substance Identification
Substance Name
Linaclotide
CAS Registry Number
851199-59-2
Drug Class
Breast Feeding
Lactation
Milk, Human
Gastrointestinal Agents
Peptides
Guanylate Cyclase C Agonists
Laxatives
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Publication Details
Publication History
Last Revision: June 15, 2024.
Copyright
Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.
Publisher
National Institute of Child Health and Human Development, Bethesda (MD)
NLM Citation
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Linaclotide. [Updated 2024 Jun 15].