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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

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Drugs and Lactation Database (LactMed®) [Internet].

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Formoterol

Last Revision: July 15, 2024.

Estimated reading time: 1 minute

CASRN: 73573-87-2

image 135012066 in the ncbi pubchem database

Drug Levels and Effects

Summary of Use during Lactation

Although no published data exist on the use of formoterol by inhaler during lactation, data from the related drug, terbutaline, indicate that very little is expected to be excreted into breastmilk.[1-3] The authors of several reviews and expert guidelines agree that use of inhaled bronchodilators is acceptable during breastfeeding because of the low bioavailability and maternal serum levels after use.[4-8]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Salmeterol

References

1.
Lindberg C, Boréus LO, de Château P, et al. Transfer of terbutaline into breast milk. Eur J Respir Dis Suppl 1984;134:87-91 [PubMed: 6586490]
2.
Boréus LO, de Château P, Lindberg C, et al. Terbutaline in breast milk. Br J Clin Pharmacol 1982;13:731-2 [PMC free article: PMC1402089] [PubMed: 7082542]
3.
Lönnerholm G, Lindström B. Terbutaline excretion into breast milk. Br J Clin Pharmacol 1982;13:729-30 [PMC free article: PMC1402083] [PubMed: 7082541]
4.
McDonald CF, Burdon JGW. Asthma in pregnancy and lactation. A position paper for the Thoracic Society of Australia and New Zealand. Med J Aust 1996;165:485-8 [PubMed: 8937369]
5.
Nelson-Piercy C. Asthma in pregnancy. Thorax 2001;56:325-8 [PMC free article: PMC1746013] [PubMed: 11254828]
6.
Taddio A, Ito S. Drugs and breast-feeding. In, Koren G, ed. Maternal-fetal toxicology. A clinician's guide. 3rd ed. New York. Marcel Dekker. 2001:177-32
7.
National Institutes of Health. National Heart, Lung and Blood Institute. Evidence-based management of sickle cell disease. Expert panel report. 2014. http://www​.nhlbi.nih​.gov/sites/www.nhlbi​.nih.gov/files/sickle-cell-disease-report.pdf
8.
Bendien SA, de Kruif MD, Feitsma H, et al. Summary of the Dutch Multidisciplinary Practice Guideline on Asthma and Pregnancy. J Allergy Clin Immunol Pract 2024;12:1751-62 [PubMed: 38513758]

Substance Identification

Substance Name

Formoterol

CAS Registry Number

73573-87-2

Drug Class

Breast Feeding

Lactation

Milk, Human

Anti-Asthmatic Agents

Bronchodilator Agents

Beta Adrenergic Agonists

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Copyright Notice

Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Bookshelf ID: NBK500788PMID: 29999847

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