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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 298-81-7
Drug Levels and Effects
Summary of Use during Lactation
No information is available on the use of methoxsalen during breastfeeding. Expert opinion indicates that due to the photosensitizing effects of methoxsalen, breastfeeding should be withheld for 24 hours after an oral dose to allow for 95% of the drug to be eliminated in the mother's urine.[1-3] The same precaution probably applies to patients receiving methoxsalen as a part of therapy for cutaneous T-cell lymphoma. Use of topical methoxsalen is not contraindicated during breastfeeding, but avoid direct contact of the treated skin with the skin of the infant.[4,5]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
(Psoriasis) Adalimumab, Certolizumab Pegol, Etanercept, Infliximab, Phototherapy, Tretinoin
References
- 1.
- Menter A, Korman NJ, Elmets CA, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy. J Am Acad Dermatol 2010;62:114-35. [PubMed: 19811850]
- 2.
- Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol 2014;70:417.e1-10. [PubMed: 24528912]
- 3.
- Yaghi M, McMullan P, Truong TM, et al. Safety of dermatologic medications in pregnancy and lactation: An Update - Part II: Lactation. J Am Acad Dermatol 2024. [PubMed: 38280680]
- 4.
- Reed BR. Dermatologic drug use during pregnancy and lactation. Dermatol Clin 1997;15:197-206. [PubMed: 9001872]
- 5.
- Reed BR. Dermatologic drugs, pregnancy, and lactation. A conservative guide. Arch Dermatol 1997;133:894-8. [PubMed: 9236528]
Substance Identification
Substance Name
Methoxsalen
CAS Registry Number
298-81-7
Drug Class
Breast Feeding
Milk, Human
Dermatologic Agents
Photosensitizing Agents
Coumarins
Furocoumarins
Psoralens
PUVA Therapy
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CAS No. 298-81-7) in F344/N Rats (Gavage Studies).[Natl Toxicol Program Tech Rep ...]Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CAS No. 298-81-7) in F344/N Rats (Gavage Studies).National Toxicology Program. Natl Toxicol Program Tech Rep Ser. 1989 Jul; 359:1-130.
- Pharmacokinetic and clinical comparison of two 8-methoxypsoralen brands.[Arch Dermatol Res. 1980]Pharmacokinetic and clinical comparison of two 8-methoxypsoralen brands.Andersen KE, Menne T, Gammeltoft M, Hjorth N, Larsen E, Solgaard P. Arch Dermatol Res. 1980; 268(1):23-9.
- Review Pyrazinamide.[Drugs and Lactation Database (...]Review Pyrazinamide.. Drugs and Lactation Database (LactMed®). 2006
- A new liquid formulation of 8-methoxypsoralen: bioactivity and effect of diet.[J Invest Dermatol. 1984]A new liquid formulation of 8-methoxypsoralen: bioactivity and effect of diet.Levins PC, Gange RW, Momtaz-T K, Parrish JA, Fitzpatrick TB. J Invest Dermatol. 1984 Feb; 82(2):185-7.
- Review Glycolic Acid.[Drugs and Lactation Database (...]Review Glycolic Acid.. Drugs and Lactation Database (LactMed®). 2006
- Methoxsalen - Drugs and Lactation Database (LactMed®)Methoxsalen - Drugs and Lactation Database (LactMed®)
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