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Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 71

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This volume Provides re-evaluations of the carcinogenic risks to humans posed by exposure to some 121 organic compounds, mostly industrial chemicals, selected from among the 834 agents evaluated in volumes 1-70 of the IARC Monographs series. Chemicals were selected for re-evaluation on the basis of considerable new evidence that might call for a change in the IARC classification of carcinogenic risk. The evaluations are presented in three parts. Part one provides full assessments of all relevant data on experimental carcinogenesis and cancer epidemiology for four chemicals: acrylonitrile, 1,3-butadiene, chloroprene, and dichloromethane. Of these, 1,3-butadiene remained classified as probably carcinogenic to humans, and dichloromethane remained classified as possibly carcinogenic to humans. Acrylonitrile, previously classified as probably carcinogenic to humans, was reclassified as possibly carcinogenic. For chloroprene, previously judged not classifiable, new epidemiological evidence and new bioassays demonstrating carcinogenicity in rats and mice supported classification as possibly carcinogenic to humans.

Part two re-evaluates 30 compounds for which new epidemiological or experimental carcinogenicity data were available and for which changes in classification were anticipated. Part three provides brief updates for 76 compounds and groups of compounds for which new evidence was restricted to experimental carcinogenicity data. As no new epidemiological evidence was available, and no reclassification was anticipated, these monographs reproduce the previous summary evaluations and update these with descriptions of new data.

Contents

Corrigenda to the IARC Monographs are published online at http://monographs.iarc.fr/ENG/Publications/corrigenda.php.

Corrigenda to Volume 71. (PDF, 38K)

LIBRARY CATALOGUING DATA

This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 17–24 February 1998

Lyon, France - 1999

IARC MONOGRAPHS

In 1969, the International Agency for Research on Cancer (IARC) initiated a programme on the evaluation of the carcinogenic risk of chemicals to humans involving the production of critically evaluated monographs on individual chemicals. The programme was subsequently expanded to include evaluations of carcinogenic risks associated with exposures to complex mixtures, life-style factors and biological agents, as well as those in specific occupations.

The objective of the programme is to elaborate and publish in the form of monographs critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations; to evaluate these data in terms of human risk with the help of international working groups of experts in chemical carcinogenesis and related fields; and to indicate where additional research efforts are needed.

The lists of IARC evaluations are regularly updated and are available on Internet: http://www.iarc.fr/.

This project has been supported by Cooperative Agreement 5 UO1 CA33193 awarded by the United States National Cancer Institute, Department of Health and Human Services. Additional support has been provided since 1986 by the European Commission, since 1993 by the United States National Institute of Environmental Health Sciences and since 1995 by the United States Environmental Protection Agency through Cooperative Agreement Assistance CR 824264.

  • ©International Agency for Research on Cancer, 1999

IARC Library Cataloguing in Publication Data

Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide /

  • IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1999 : Lyon, France).
  • (IARC monographs on the evaluation of carcinogenic risks to humans; 71 part 1, part 2 and part 3)
  • 1. Carcinogens – congresses 2. Occupational Exposure – congresses I. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans II. Series
  • ISBN 92 832 1271 1 (NLM Classification: W1)
  • ISSN 1017-1606

Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention.

All rights reserved. Application for rights of reproduction or translation, in part or in toto, should be made to the International Agency for Research on Cancer.

Distributed by IARCPress (Fax: +33 4 72 73 83 02; E-mail: rf.crai@sserp) and by the World Health Organization Distribution and Sales, CH-1211 Geneva 27 (Fax: +41 22 791 4857)

PRINTED IN FRANCE

©International Agency for Research on Cancer, 1999.
Bookshelf ID: NBK498701

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