Structured Abstract

Contents

• Preface
• Key Informants
• Technical Expert Panel
• Peer Reviewers
• Evidence Summary
• Introduction
  • Background
  • Key Questions
  • Analytic Framework
• Methods
  • Eligibility Criteria
  • Evidence Identification
  • Data Extraction and Data Management
  • Assessment of Methodological Risk of Bias of Individual Studies
  • Data Synthesis
  • Presentation of Results
  • Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes
  • Peer Review
• Results
  • Summary of Studies
  • Basal Cell Carcinoma
  • Squamous Cell Carcinoma
  • Microinvasive SCC Lesions
• Discussion
  • Evidence Summary
  • Evidence Limitations
  • Future Research Recommendations
  • Conclusions
• References
• Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin: BCC Addendum
• Appendix A. Search Strategy
• Appendix B. Excluded Studies
• Appendix C. Design Details
• Appendix D. Baselines
• Appendix E. Arm Details
• Appendix F. Risk of Bias
• Appendix G. Summary Results From Unadjusted NRCS
• Appendix H. Adverse Events Reported
• Appendix I. Study-Level Results

Suggested citation:

Drucker A, Adam GP, Langberg V, Gazula A, Smith B, Moustafa F, Weinstock MA, Trikalinos TA. Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin. Comparative Effectiveness Review No. 199. (Prepared by the Brown Evidence-based Practice Center under Contract No. 290-2015-00002-I.) AHRQ Publication No. 17(18)-EHC033-EF. Rockville, MD: Agency for Healthcare Research and Quality; December 2017. www.effectivehealthcare.ahrq.gov/reports/final.cfm.

This report is based on research conducted by the Brown Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2015-00002-I). The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report.

The information in this report is intended to help health care decisionmakers—patients and clinicians, health system leaders, and policymakers, among others—make well-informed decisions and thereby improve the quality of health care services. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances presented by individual patients.

AHRQ or U.S. Department of Health and Human Services endorsement of any derivative products that may be developed from this report, such as clinical practice guidelines, other quality enhancement tools, or reimbursement or coverage policies, may not be stated or implied. This report may periodically be assessed for the currency of conclusions. If an assessment is done, the resulting surveillance report describing the methodology and findings will be found on the Effective Health Care Program Web site at www.effectivehealthcare.ahrq.gov. Search on the title of the report.

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