Structured Abstract

Contents

• Preface
• Technical Expert Panel
• Peer Reviewers
• Evidence Summary
• Introduction
  • Background
  • Purpose and Scope of the Systematic Review
  • Key Questions (KQs)
• Methods
  • Criteria for Inclusion/Exclusion of Studies in the Review
  • Literature Search Strategies
  • Data Abstraction and Data Management
  • Assessment of Methodological Risk of Bias of Individual Studies
  • Data Synthesis
  • Grading the Strength of Evidence for Major Comparisons and Outcomes
  • Assessing Applicability
  • Peer Review and Public Commentary
• Results
  • Search Results
  • Analysis Results
• Discussion
  • Findings in Relation to What Is Known
  • Limitations
  • Applicability
  • Suggestions for Future Research
• Conclusion
• References
• Abbreviations
• Appendix A. Search Strategy
• Appendix B. Excluded Studies
• Appendix C. Description of Included Studies
• Appendix D. Figures
• Appendix E. Subgroup Analyses
• Appendix F. Sensitivity Analysis
• Appendix G. Risk of Bias
• Appendix H. Assessment of the Strength of Evidence
• Appendix I. Additional Tables
• Appendix J. References

Suggested citation:

Wang Z, Pianosi P, Keogh K, Zaiem F, Alsawas M, Alahdab F, Almasri JM, Mohammed K, Larrea-Mantilla L, Farah W, Daraz L, Barrionuevo P, Gunjal S, Prokop LJ, Murad MH. The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management. Comparative Effectiveness Review No. 197 (Prepared by the Mayo Clinic Evidence-based Practice Center under Contract No. 290-2015-00013-I). AHRQ Publication No.17(18)-EHC030-EF. Rockville, MD: Agency for Healthcare Research and Quality. December 2017. www.effectivehealthcare.ahrq.gov/reports/final.cfm.

This report is based on research conducted by Mayo Clinic Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2015-00013-I). The National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) sponsor the report. The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ or NIH/NHLBI. Therefore, no statement in this report should be construed as an official position of AHRQ, NIH/NHLBI or of the U.S. Department of Health and Human Services.

None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report.

The information in this report is intended to help health care decision makers—patients and clinicians, health system leaders, and policymakers, among others—make well-informed decisions and thereby improve the quality of health care services. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances presented by individual patients.

AHRQ or U.S. Department of Health and Human Services endorsement of any derivative products that may be developed from this report, such as clinical practice guidelines, other quality enhancement tools, or reimbursement or coverage policies, may not be stated or implied.

This report may periodically be assessed for the currency of conclusions. If an assessment is done, the resulting surveillance report describing the methodology and findings will be found on the Effective Health Care Program Web site at www.effectivehealthcare.ahrq.gov. Search on the title of the report.

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