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Kansagara D, O'Neil M, Nugent S, et al. Benefits and Harms of Cannabis in Chronic Pain or Post-traumatic Stress Disorder: A Systematic Review [Internet]. Washington (DC): Department of Veterans Affairs (US); 2017 Aug.

Cover of Benefits and Harms of Cannabis in Chronic Pain or Post-traumatic Stress Disorder: A Systematic Review

Benefits and Harms of Cannabis in Chronic Pain or Post-traumatic Stress Disorder: A Systematic Review [Internet].

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Quality Assessment Criteria for Observational Studies, Based on the Newcastle-Ottawa Scale21

Representativeness of the exposed cohort
Enter 0 or 1:
1 = truly representative of the average patient in the community
1 = somewhat representative of the average patient in the community
0 = selected group of users (eg, nurses, volunteers)
0 = no description of the derivation of the cohort
Selection of the non-exposed cohort
Enter 0 or 1:
1 = drawn from the same community as the exposed cohort
0 = drawn from a different source
0 = no description of the derivation of the non-exposed cohort
Ascertainment of exposure
Enter 0 or 1:
1 = biological test (eg, blood/urine)
1 = structured interview
1 = written self-report that characterizes dose (current or cumulative)
0 = written self-report without quantification of exposure
0 = no description
Precision of Exposure Dose Ascertainment
Enter 0 or 1:
1 = amount and time
0 = no information about amount and time
Ascertainment of exposure done prospectively or retrospectively
Enter 0 or 1:
1 = Prospectively
0 = Retrospectively
Demonstration that outcome of interest was not present at start of study, OR baseline assessment
Enter 0 or 1:
1= yes
0 = no
Adjustment for confounding (rendering comparability of cohorts on the basis of the design or analysis)
Add points: Minimum 0, Maximum 2
1 = study accounts/controls for other substance use
1 = study controls for any additional factor (mental health comorbidity; medication use; severity of PTSD; mental health comorbidity and treatment; socioeconomic status)
0 = no adjustment for potential confounders
Assessment of outcome
Enter 0 or 1:
1 = objective measure
1 = validated self-report measures
0 = no information or non-validated measures
Was follow-up long enough for outcomes to occur?
Enter 0 or 1:
1 = yes (need to define adequate follow-up period for outcome of interest)
0 = no
Adequacy of follow-up of cohorts
Enter 0 or 1:
1 = complete follow-up; all subjects accounted for.
1 = subjects lost to follow-up unlikely to introduce bias; small number (less than 20 %) lost, or description was provided of those lost.
0 = follow-up rate < 80% and no description of those lost.
0 = no statement

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