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Cover of Neurobiology of TRP Channels

Neurobiology of TRP Channels

Editor: Tamara Luti Rosenbaum Emir.

Boca Raton (FL): CRC Press/Taylor & Francis; .
ISBN-13: 9781315152837 (ebook)ISBN-13: 9781498755245 (hardback)

Biomedical Science

During the last two decades, there has been an explosion of research pertaining to the molecular mechanisms that allow for organisms to detect different stimuli, an essential feature for their survival. Among these mechanisms, living beings need to be able to respond to different temperatures as well as chemical and physical stimuli.

Thermally activated ion channels were proposed to be present in sensory neurons in the 1980s, but it was not until 1997 that a heat- and capsaicin- activated ion channel, TRPV1, was cloned and its function described in detail. This groundbreaking discovery led to the identification and characterization of several more proteins of the family of Transient Receptor Potential (TRP) ion channels.

Intensive research has provided us with the atomic structures of some of these proteins, as well as understanding of their physiological roles, both in normal and pathological conditions. With chapters contributed by renowned experts in the field, Neurobiology of TRP Channels contains a state-of-the-art overview of our knowledge of TRP channels, ranging from structure to their functions in organismal physiology.

Features

  • Contains chapters on the roles of several TRP ion channels with a diversity of physiological functions, providing a complete picture of the widespread importance of these proteins.
  • Presents an overview of the structure of TRP channels, including the roles of these proteins in different physiological processes.
  • Discusses the roles of TRP channels in pathophysiological processes, further highlighting their importance.
  • Features several full color illustrations to allow the reader better comprehension of TRP channels.

A volume in the Frontiers in Neuroscience series

Contents

Cover figures:

Structures for the TRPA1 (PDB: 3J9P; Paulsen et al., Nature 2015:520); TRPV1 (PDB: 3J5P; Liao et al., Nature 2013:504); TRPV2 (PDB: 5HI9; Huynh et al., Nature Communications 2016:7); and the TRPP2 Ion Channels (PDB: 5MKE; Wilkes et al., Nature Structural and Molecular Biology 2017:24).

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Names: Rosenbaum Emir, Tamara Luti.

Title: Neurobiology of TRP channels / [edited by] Tamara Luti Rosenbaum Emir.

Other titles: Neurobiology of transient receptor potential channels

Description: Boca Raton : CRC Press, 2017. | Includes bibliographical references.

Identifiers: LCCN 2017008322| ISBN 9781498755245 (hardback) | ISBN 9781315152837 (e-book)

Subjects: LCSH: TRP channels. | Membrane proteins. | Ion channels. | Neurobiology. | Biochemistry.

Classification: LCC QP552.T77 N48 2017 | DDC 572/.696–dc23

LC record available at https://lccn.loc.gov/2017008322

SPiGlobal

To Maia, Meryem, Marcos, León, and Mustafa

© 2018 by Taylor & Francis Group, LLC.
Bookshelf ID: NBK476116PMID: 29356469DOI: 10.4324/9781315152837

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