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Biomedical Science
During the last two decades, there has been an explosion of research pertaining to the molecular mechanisms that allow for organisms to detect different stimuli, an essential feature for their survival. Among these mechanisms, living beings need to be able to respond to different temperatures as well as chemical and physical stimuli.
Thermally activated ion channels were proposed to be present in sensory neurons in the 1980s, but it was not until 1997 that a heat- and capsaicin- activated ion channel, TRPV1, was cloned and its function described in detail. This groundbreaking discovery led to the identification and characterization of several more proteins of the family of Transient Receptor Potential (TRP) ion channels.
Intensive research has provided us with the atomic structures of some of these proteins, as well as understanding of their physiological roles, both in normal and pathological conditions. With chapters contributed by renowned experts in the field, Neurobiology of TRP Channels contains a state-of-the-art overview of our knowledge of TRP channels, ranging from structure to their functions in organismal physiology.
Features
- Contains chapters on the roles of several TRP ion channels with a diversity of physiological functions, providing a complete picture of the widespread importance of these proteins.
- Presents an overview of the structure of TRP channels, including the roles of these proteins in different physiological processes.
- Discusses the roles of TRP channels in pathophysiological processes, further highlighting their importance.
- Features several full color illustrations to allow the reader better comprehension of TRP channels.
A volume in the Frontiers in Neuroscience series
Contents
- PrefaceEditor: Tamara Luti Rosenbaum Emir.
- Editor
- List of Contributors
- 1. TRP Channels: What Do They Look Like?Mario G. Rosasco and Sharona E. Gordon.
- 2. Molecular Mechanisms of Temperature Gating in TRP ChannelsLeón D. Islas.
- 3. TRP Channels in VisionBen Katz, Richard Payne, and Baruch Minke.
- 4. Sensory Mechanotransduction and Thermotransduction in InvertebratesShana Geffeney.
- 5. Osmomechanical-Sensitive TRPV Channels in MammalsCarlene Moore and Wolfgang B. Liedtke.
- 6. A Critical Role for TRP Channels in the SkinPu Yang, Jing Feng, Jialie Luo, Mack Madison, and Hongzhen Hu.
- 7. TRP Channels at the Periphery of the Taste and Trigeminal SystemsSidney A. Simon and Ranier Gutierrez.
- 8. TRP Channels and PainRicardo González-Ramírez, Yong Chen, Wolfgang B. Liedtke, and Sara L. Morales-Lázaro.
- 9. TRP Channels in the HeartMarc Freichel, Michael Berlin, Alexander Schürger, Ilka Mathar, Lucas Bacmeister, Rebekka Medert, Wiebke Frede, André Marx, Sebastian Segin, and Juan E. Camacho Londoño.
- 9.1. Introduction
- 9.2. Expression of TRPs in cardiac cells
- 9.3. TRP proteins and their contribution to Ca2+ signaling in cardiac cells
- 9.4. Role of TRPs in cardiac fibroblasts
- 9.5. Regulation of Cardiac Contractility by TRP Channels
- 9.6. Regulation of cardiac remodeling by TRP channels in vivo
- 9.7. TRP channels in the regulation of cardiac conduction and their contribution to arrhythmias
- Acknowledgment/Funding
- References
- 10. Renal Functions of TRP Channels in Health and DiseaseVladimir Chubanov, Sebastian Kubanek, Susanne Fiedler, Lorenz Mittermeier, Thomas Gudermann, and Alexander Dietrich.
- 10.1. Kidney Function and Expression of Trp Channels
- 10.2. Trpc Channels in Kidney Function and Disease
- 10.3. Regulation of Trpc1 Expression in Glomerular Mesangial Cells
- 10.4. Trpc3 And Its Role In Renal Fibrosis
- 10.5. Trpc5 Function During Kidney Injury
- 10.6. Physiological Role of Trpc6 and Altered Function by Inherited Mutations in The Kidney
- 10.7. Expression and Function of Trpm7 and Trpm6 Channels in the Kidney
- 10.8. Genome-Wide Associations With TRPM6
- 10.9. Conclusion
- Acknowledgments
- References
- 11. Fertility and TRP ChannelsIda Björkgren and Polina V. Lishko.
- 12. The Role of TRP Channels in the Pancreatic Beta-CellKoenraad Philippaert and Rudi Vennekens.
- 13. Airway Pathogenesis Is Linked to TRP ChannelsHelen Wallace.
- 14. ThermoTRPs: Role in AgingCeline Emmanuelle Riera.
- 15. Roles of Neuronal TRP Channels in Neuroimmune InteractionsAlejandro López-Requena, Brett Boonen, Laura Van Gerven, Peter W. Hellings, Yeranddy A. Alpizar, and Karel Talavera.
- 15.1. Introduction
- 15.2. TRP Channels as Effectors of Pathogen-Derived Cues
- 15.3. Neuronal TRP channels as sensors of immune system effectors
- 15.4. Neuronal TRP Channels in Immune-Related Disorders in the Gut and Airways
- 15.5. Neuronal TRPs in other inflammatory processes
- 15.6. Concluding Remarks
- Acknowledgments
- References
- 16. TRP Channels in the Brain: What Are They There For?Seishiro Sawamura, Hisashi Shirakawa, Takayuki Nakagawa, Yasuo Mori, and Shuji Kaneko.
Cover figures:
Structures for the TRPA1 (PDB: 3J9P; Paulsen et al., Nature 2015:520); TRPV1 (PDB: 3J5P; Liao et al., Nature 2013:504); TRPV2 (PDB: 5HI9; Huynh et al., Nature Communications 2016:7); and the TRPP2 Ion Channels (PDB: 5MKE; Wilkes et al., Nature Structural and Molecular Biology 2017:24).
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Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe.
Names: Rosenbaum Emir, Tamara Luti.
Title: Neurobiology of TRP channels / [edited by] Tamara Luti Rosenbaum Emir.
Other titles: Neurobiology of transient receptor potential channels
Description: Boca Raton : CRC Press, 2017. | Includes bibliographical references.
Identifiers: LCCN 2017008322| ISBN 9781498755245 (hardback) | ISBN 9781315152837 (e-book)
Subjects: LCSH: TRP channels. | Membrane proteins. | Ion channels. | Neurobiology. | Biochemistry.
Classification: LCC QP552.T77 N48 2017 | DDC 572/.696–dc23
LC record available at https://lccn.loc.gov/2017008322
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