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Probe Reports from the NIH Molecular Libraries Program [Internet].
Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Table of contents
Discovery of a Highly Selective KCC2 Antagonist.
Lindsley C, Lewis M, Weaver D, et al. 2009 Feb 1 [Updated 2010 Oct 4].
Novel Chemical Inhibitor of TRPC4 Channels.
Miller MR, Shi J, Wu M, et al. 2010 Dec 15 [Updated 2011 May 26].
Discovery of a small molecule inhibitor of ROMK with unprecedented selectivity.
Denton JS, Weaver CD, Chauder BA, et al. 2009 Sep 1 [Updated 2010 Oct 20].
Identification of Potent and Selective Thyroid Stimulating Hormone Receptor Agonists.
Titus S, Huang W, Marugan J, et al. 2009 Sep 1 [Updated 2011 Mar 25].
Development of the First CNS penetrant M5 Positive Allosteric Modulator (PAM) Based on a Novel, non-Isatin Core.
Gentry PR, Kokubo M, Bridges TM, et al. 2013 Dec 15 [Updated 2015 Feb 11].
Discovery of ML366, an inhibitor of Vibrio cholerae Quorum Sensing Acting via the LuxO response regulator.
Faloon P, Jewett I, Youngsaye W, et al. 2013 Apr 12 [Updated 2014 Sep 18].
ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV).
Chung D, Schroeder CE, Sotsky J, et al. 2012 Dec 17 [Updated 2013 Nov 7].
ML365: Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two Pore Potassium Channel.
Zou B, Flaherty DP, Simpson DS, et al. 2013 Apr 15 [Updated 2013 Nov 14].
Discovery, optimization, and biological activity of the first potent and selective small-molecule agonist series of human relaxin receptor 1 (RXFP1).
Xiao J, Chen CZ, Huang Z, et al. 2012 Mar 10 [Updated 2013 May 8].
Development and characterization of a highly selective M5 PAM probe molecule with improved potency.
Gentry PR, Bridges TM, Daniels JS, et al. 2012 Dec 13 [Updated 2013 Mar 22].
Selective small molecule activator of the apoptotic arm of the UPR.
Flaherty DP, Golden JE, Liu C, et al. 2012 Apr 1 [Updated 2013 Feb 28].
N-(pyridin-4-yl)benzo[d]thiazole-6-carboxamide inhibits E. coli UT189 bacterial capsule biogenesis.
Noah JW, Ananthan S, Evans CW, et al. 2012 Dec 17 [Updated 2013 Apr 5].
ML322, A Small Molecule Inhibitor of Dimerization of the Core Protein of Hepatitis C Virus (HCV).
Kota S, Madoux F, Chase P, et al. 2012 Dec 17 [Updated 2014 May 13].
Identification of a Novel Agonist of the Sphingosine 1-phosphate Receptor 4 (S1P4).
Guerrero M, Urbano M, Velaparthi S, et al.
A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7.
Hong L, Simons P, Waller A, et al. 2011 Dec 16 [Updated 2013 Mar 7].
Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction.
Manka J, Daniels RN, Dawson E, et al. 2011 Mar 31 [Updated 2013 Feb 28].
Discovery of a Highly Selective in vitro and in vivo M1 Allosteric Agonist Probe.
Lindsley C, Lewis M, Weaver D. 2008 Dec 3 [Updated 2010 Oct 4].
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator (PAM).
Lewis LM, Bridges TM, Niswender CM, et al. 2009 Sep 1 [Updated 2010 Oct 20].
Identification of a Series of Quinazolinediones as Potent, Selective, Post-Entry Inhibitors of Human Respiratory Syncytial Virus (hRSV) via a Cell-Based High Throughput Screen and Chemical Optimization.
Noah JW, Severson WE, Chung DH, et al. 2011 Dec 16 [Updated 2013 Feb 28].
Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2).
Busby S, Nuhant P, Cameron M, et al. 2010 Oct 12 [Updated 2011 Dec 12].
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