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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Figure 4MDS Pharma Lead Profiling Screen of 68 GPCRs, ion channels and transporters against CID 25067404 (ML077) (SID-56405641) at a concentration of 10 μM.
| Targ | Species | % Inhibition (10 μM) CID 25067404 |
|---|---|---|
| Adenosine A1 | human | 31 |
| Adenosine A2 | human | 38 |
| Adenosine A3 | human | 38 |
| Adrenergic α1A | rat | 33 |
| Adrenergic α1B | rat | 3 |
| Adrenergic α1D | human | 16 |
| Adrenergic α2A | human | −7 |
| Adrenergic β1 | human | 10 |
| Adrenergic β2 | human | 9 |
| Androgen (testosterone)AR | rat | 4 |
| Bradykinin B1 | human | 6 |
| Bradykinin B2 | human | 2 |
| Calcium channel L-type, benzothiazepine | rat | 10 |
| Calcium channel L-type, dihydropyridine | rat | −2 |
| Calcium channel N-type | rat | −4 |
| Dopamine D1 | human | 8 |
| Dopamine D2S | human | −3 |
| Dopamine D3 | human | −1 |
| Dopamine D4.2 | human | −12 |
| Endothelin ETA | human | 0 |
| Endothelin ETB | human | −3 |
| Epidermal Growth Factor (EGF) | human | −1 |
| Estrogen ER α | human | 10 |
| G protein-coupled receptor GPR103 | human | 12 |
| GABAA Flunitrazepam, central | rat | 25 |
| GABAA Muscimol, central | rat | 1 |
| GABAB1A | human | 1 |
| Glucocorticoid | human | 7 |
| Glutamate, Kainate | rat | 11 |
| Glutamate, NMDA, Agonism | rat | 33 |
| Glutamate, NMDA, Glycine | rat | 6 |
| Glutamate, NMDA, Phencyclidine | rat | 2 |
| Histamine H1 | human | 7 |
| Histamine H2 | human | 7 |
| Histamine H3 | human | 7 |
| Imidazoline I2, Central | rat | 6 |
| Interleukin IL-1 | mouse | 6 |
| Leukotriene, Cysteinyl CysLT1 | human | 10 |
| Melatonin MT1 | human | 7 |
| Muscarinic M1 | human | 2 |
| Muscarinic M2 | human | −9 |
| Muscarinic M3 | human | 5 |
| Neuropeptide Y Y1 | human | 3 |
| Neuropeptide Y Y2 | human | 9 |
| Nicotinic Acetylcholine | human | 3 |
| Nicotinic Acetylcholine 1 α, Bungarotoxin | human | 1 |
| Opiateδ (OP1, DOP) | human | 20 |
| Opiate κ (OP2, KOP) | human | −11 |
| Opiate μ (OP3, MOP) | human | −3 |
| Phorbol Ester | mouse | 24 |
| Platelet Activating Factor (PAF) | human | 4 |
| Potassium Channel [KATP] | hamster | 10 |
| Potassium Channel hERG | human | 10 |
| Prostanoid EP4 | human | −4 |
| Purinergic P2X | rabbit | −18 |
| Purinergic P2Y | rat | 8 |
| Rolipram | rat | 3 |
| Serotonin (5-Hydroxytryptamine) 5-HT1A | human | 15 |
| Serotonin (5-Hydroxytryptamine) 5-HT3 | human | −7 |
| Sigma σ1 | human | −5 |
| Sigma σ2 | rat | 15 |
| Sodium Channel, Site 2 | rat | 0 |
| Tachykinin NK1 | human | −10 |
| Thyroid Hormone | rat | 3 |
| Transporter, Dopamine (DAT) | human | 28 |
| Transporter, GABA | rat | 0 |
| Transporter, Norepinephrine (NET) | human | 34 |
| Transporter, Serotonin (5-Hydroxytryptamine) (SERT) | human | 2 |
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- Figure 4, MDS Pharma Lead Profiling Screen of 68 GPCRs, ion channels and transpo...Figure 4, MDS Pharma Lead Profiling Screen of 68 GPCRs, ion channels and transporters against CID 25067404 (ML077) (SID-56405641) at a concentration of 10 μM. - Probe Reports from the NIH Molecular Libraries Program
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