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StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-.
Metabolic Pathway for Bilirubin in the Hepatocyte. Bilirubin-G corresponds to bilirubin glucuronate; the donor is uridine diphosphate glucuronic acid (UDP-GA). This is catalyzed by the enzyme uridine diphosphate-glucuronyltransferase (UGT1A1). Gilbert and Crigler-Najjar syndrome is associated with decreases in UGT1A1 activity. Glutathione-S-transferase (GST) is a carrier protein that assists bilirubin uptake into the cytosol and may be implicated in Rotor syndrome. Contributed by R Kabir, MD
From: Physiology, Bilirubin
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