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Williamson E, Sathe NA, Andrews JC, et al. Medical Therapies for Children With Autism Spectrum Disorder—An Update [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2017 May. (Comparative Effectiveness Reviews, No. 189.)
Medical Therapies for Children With Autism Spectrum Disorder—An Update [Internet].
Show detailsTable D-1Risk of bias assessments
First Author Year | Group Design | Random Assignment | Appropriate Comparison Group | Correct Randomization | Systematic Diagnostic Approach | Clear Sample Characterization | Clear Inclusion/Exclusion Criteria | Attrition Reported | Drop out Characteristics Evaluated | Intervention Fully Described | Treatment Fidelity Monitored | Treatment Adherence Measured and Reported | Concomitant Interventions Held Steady/Reported | Outcome Measures Reliable and Valid | Primary Outcomes Specified a priori | Outcome Data Collected From Appropriate Sources | Outcomes Coded Blindly | Appropriate Statistical Analysis | Rating |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aman 20161 | + | + | + | + | ++ | + | + | + | − | + | NA | + | + | + | + | + | + | − | Low |
Aman 20152–12 | + | + | + | + | ++ | + | + | + | + | + | + | + | + | + | + | + | + | + | Low |
Amatachaya 201513, 14 | + | + | + | + | + | − | + | − | NA | + | NA | + | + | + | + | + | + | − | Moderate |
Arnold 201215 | + | + | + | + | ++ | + | + | + | NA | + | NA | + | + | + | + | + | + | − | Low |
Akhondzadeh 201016 | + | + | + | + | − | − | + | NA | NA | + | NA | − | − | + | + | + | + | − | Moderate |
Akhondzadeh 200817 | + | + | + | + | − | − | + | + | NA | + | NA | − | + | + | + | + | + | + | Moderate |
Arnold 200618 | + | + | + | − | + | + | + | + | − | + | NA | − | + | + | + | + | + | − | moderate |
Al Ayadhi 201319 | + | + | + | − | + | − | − | + | NA | + | − | − | + | + | + | + | + | − | High |
Asadabadi 201320 | + | + | + | + | ++ | + | + | + | NA | + | NA | + | + | + | + | + | + | − | Low |
Bent 201421 | + | + | − | + | − | + | + | + | NA | + | NA | + | + | + | + | + | + | − | Moderate |
Bent 201122 | + | + | + | + | ++ | + | + | + | NA | + | NA | + | + | + | + | + | + | + | Low |
Bertoglio 201023 | + | + | + | − | ++ | + | + | + | NA | + | NA | + | + | + | + | + | + | − | Low |
Chugani 201624 | + | + | + | − | ++ | + | + | + | − | + | NA | + | + | + | + | + | + | − | Low |
Cortesi 201225 | + | + | + | + | ++ | + | + | + | + | + | NA | + | + | + | + | + | + | − | Low |
Chez 200326 | + | + | + | − | + | + | + | + | + | + | NA | − | + | + | + | + | + | − | Moderate |
Dean 201627 | + | + | + | + | + | + | + | + | − | + | NA | + | + | + | + | + | − | − | Moderate |
Dadds 201428 | + | + | + | − | + | + | + | + | − | + | NA | + | + | + | − | + | + | − | Low |
Duffy 201429 | + | − | − | NA | + | − | + | − | NA | + | NA | + | + | − | + | − | − | − | High |
Findling 201430 | + | + | + | − | ++ | + | + | + | − | + | NA | − | + | + | + | + | + | + | Low |
Fahmy 201331 | + | + | + | − | − | + | + | + | − | + | NA | − | − | + | − | + | + | − | Moderate |
Ghaleiha 201632 | + | + | + | + | ++ | + | + | + | NA | + | NA | + | + | + | + | + | + | − | Low |
Ghalichi 201633 | + | + | + | − | − | + | + | + | NA | + | NA | + | − | + | + | + | − | − | High |
Ghanizadeh 201434 | + | + | + | − | ++ | + | + | + | − | + | NA | + | + | + | + | + | + | + | Low |
Geier 201135 | + | + | + | − | − | − | − | + | − | + | NA | + | + | + | + | + | + | − | High |
Granpeesheh 201036 | + | + | + | − | ++ | − | + | + | − | + | NA | + | + | + | + | + | + | + | Low |
Ghaleiha 201537 | + | + | + | + | ++ | + | + | + | NA | + | NA | + | + | + | + | + | + | − | Low |
Ghaleiha 201338 | + | + | + | + | ++ | + | + | + | − | + | NA | + | + | + | + | + | + | + | Low |
Ghaleiha 201339 | + | + | + | + | ++ | + | + | + | NA | + | NA | + | + | + | + | + | + | − | Low |
Ghaleiha 201340 | + | + | + | + | ++ | + | + | + | − | + | NA | + | + | + | + | + | + | − | Low |
Ghanizadeh 201541 | + | + | + | + | ++ | − | + | + | − | + | NA | − | + | + | + | + | + | + | Low |
Ghanizadeh 201342 | + | + | + | + | ++ | − | + | + | − | + | NA | − | + | + | + | + | + | + | Low |
Hendren 201643 | + | + | + | + | + | + | + | + | − | + | NA | + | − | + | + | + | + | − | Moderate |
Handen 201544, 45 | + | + | + | + | ++ | + | + | + | − | + | NA | + | + | + | + | + | + | − | Low |
Hyman 201546 | + | + | + | + | ++ | + | + | + | NA | + | NA | + | + | + | + | + | + | − | Low |
Handen 201147 | + | + | + | − | ++ | + | + | + | NA | + | NA | + | + | + | + | + | + | + | Low |
Hollander 201048 | + | + | + | − | ++ | + | + | + | − | + | NA | + | + | + | + | + | + | + | Low |
Hardan 201249 | + | + | + | + | ++ | + | + | + | − | + | NA | + | + | + | + | + | + | − | Low |
Hasanzadeh 201250 | + | + | + | + | ++ | + | + | + | NA | + | NA | − | + | + | + | + | + | − | Low |
Harrison 200651, 52 | + | + | − | − | ++ | − | + | + | − | + | NA | − | − | + | + | + | + | − | Moderate |
Johnson 201153 | + | + | + | − | ++ | + | + | + | NA | + | NA | + | − | + | + | + | − | − | Moderate |
King 200154 | + | + | + | − | + | + | + | + | NA | + | NA | − | + | + | + | + | + | − | Moderate |
Kent 201355, 56 | + | + | + | + | ++ | + | + | + | − | + | NA | − | + | + | + | + | + | + | Low |
King 201357, 58 | + | + | + | + | ++ | + | + | + | + | + | NA | + | + | + | + | + | + | + | Low |
Klaiman 201359 | + | + | + | + | ++ | − | + | + | − | + | NA | + | + | + | + | + | + | − | Low |
Lamberti 201660 | + | + | + | − | ++ | + | + | + | − | + | NA | − | − | + | + | + | − | + | Low |
Lv 201361 | + | − | − | NA | ++ | − | + | + | NA | + | NA | + | + | + | + | + | − | + | High |
Lemonnier 201262 | + | + | + | − | ++ | + | + | + | NA | + | NA | − | + | + | + | + | + | − | Moderate |
Mankad 201563 | + | + | + | + | ++ | + | + | + | − | + | NA | + | + | + | + | + | + | − | Low |
McCracken 201464–67 | + | + | + | + | ++ | + | + | + | − | + | NA | − | + | + | + | + | + | + | Moderate |
Mohammadi 201368 | + | + | + | + | ++ | + | + | + | NA | + | NA | + | + | + | + | + | + | + | Low |
Marcus 201169–75 | + | + | + | + | ++ | + | + | + | − | + | NA | + | + | + | + | + | + | + | Low |
Munasinghe 201076 | + | + | + | − | − | − | + | + | − | + | NA | + | + | + | + | + | + | − | Moderate |
Miral 200877 | + | + | + | + | + | + | + | + | NA | + | NA | + | + | + | + | + | + | + | Moderate |
Nikvarz 201678 | + | + | + | + | + | − | + | + | − | + | NA | − | + | + | + | + | − | − | Moderate |
Navarro 201579 | + | + | + | + | ++ | + | + | + | NA | + | NA | + | − | + | + | + | + | − | Low |
Nikoo 201480 | + | + | + | + | + | + | + | + | − | + | NA | − | + | + | + | + | + | + | Moderate |
Nagaraj 200681 | + | + | + | + | + | + | + | + | − | + | NA | − | + | + | + | + | + | − | Moderate |
Pusponegoro 201582 | + | + | + | + | − | + | + | + | − | + | + | + | − | + | + | + | + | − | Moderate |
Pearson 201383 | + | + | + | − | ++ | + | + | + | NA | + | NA | + | + | + | + | + | + | + | Low |
Rezaei 201084 | + | + | + | + | ++ | + | + | + | NA | + | NA | + | + | + | + | + | + | + | Low |
Rossignol 200985 | + | + | + | + | ++ | + | + | + | + | + | NA | − | + | + | + | + | + | − | Low |
Sun 201686 | + | − | + | NA | + | + | + | + | − | + | NA | + | + | + | + | + | − | − | Moderate |
Sampanthavivat 201287 | + | + | + | + | + | − | + | + | NA | + | NA | + | − | + | + | + | + | − | Moderate |
Shea 200488, 89 | + | + | + | − | + | + | + | + | − | + | NA | + | + | + | + | + | + | − | Moderate |
Saad 201590 | + | + | + | + | ++ | + | − | + | NA | + | NA | − | + | + | + | + | + | − | Moderate |
Scahill 201591 | + | + | + | + | ++ | + | + | + | + | + | NA | + | + | + | + | + | + | + | Low |
Shan 201592 | + | + | + | − | − | − | + | + | − | + | NA | − | − | + | − | + | − | − | High |
Troost 200593 | + | + | + | − | ++ | + | + | + | NA | + | NA | − | + | + | + | + | + | + | Low |
Voigt 201494 | + | + | + | + | ++ | + | + | + | − | + | NA | + | + | + | + | + | + | + | Low |
Van der Meer 201395–98 | + | + | + | + | ++ | + | + | + | NA | + | NA | + | + | + | + | + | + | − | Low |
Wink 201499 | + | − | + | NA | + | + | − | − | − | + | − | + | + | + | + | − | + | + | Moderate |
Wright 2011100 | + | + | + | + | ++ | + | + | + | − | + | NA | + | + | + | + | + | + | − | Low |
Whiteley 2010101, 102 | + | + | + | − | ++ | + | + | + | − | + | NA | + | + | + | + | + | − | − | Moderate |
Wasserman 2006103 | + | + | + | − | ++ | + | + | + | − | + | NA | − | + | + | + | + | + | − | Low |
Danfors 2005104 | + | + | + | − | + | + | + | + | NA | + | NA | + | − | + | + | + | + | + | Moderate |
Knivsberg 2002105_4575 | + | + | + | − | − | + | + | + | NA | − | NA | − | − | + | + | + | + | − | High |
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- Risk of Bias Ratings - Medical Therapies for Children With Autism Spectrum Disor...Risk of Bias Ratings - Medical Therapies for Children With Autism Spectrum Disorder—An Update
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