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Williamson E, Sathe NA, Andrews JC, et al. Medical Therapies for Children With Autism Spectrum Disorder—An Update [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2017 May. (Comparative Effectiveness Reviews, No. 189.)

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Medical Therapies for Children With Autism Spectrum Disorder—An Update [Internet].

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Appendix DRisk of Bias Ratings

Table D-1Risk of bias assessments

First Author YearGroup DesignRandom AssignmentAppropriate Comparison GroupCorrect RandomizationSystematic Diagnostic ApproachClear Sample CharacterizationClear Inclusion/Exclusion CriteriaAttrition ReportedDrop out Characteristics EvaluatedIntervention Fully DescribedTreatment Fidelity MonitoredTreatment Adherence Measured and ReportedConcomitant Interventions Held Steady/ReportedOutcome Measures Reliable and ValidPrimary Outcomes Specified a prioriOutcome Data Collected From Appropriate SourcesOutcomes Coded BlindlyAppropriate Statistical AnalysisRating
Aman 20161++++++++++NA++++++Low
Aman 2015212+++++++++++++++++++Low
Amatachaya 201513, 14++++++NA+NA++++++Moderate
Arnold 201215+++++++++NA+NA++++++Low
Akhondzadeh 201016+++++NANA+NA++++Moderate
Akhondzadeh 200817++++++NA+NA++++++Moderate
Arnold 200618++++++++NA+++++moderate
Al Ayadhi 201319+++++NA++++++High
Asadabadi 201320+++++++++NA+NA++++++Low
Bent 201421++++++NA+NA++++++Moderate
Bent 201122+++++++++NA+NA+++++++Low
Bertoglio 201023++++++++NA+NA++++++Low
Chugani 201624+++++++++NA++++++Low
Cortesi 201225+++++++++++NA++++++Low
Chez 200326+++++++++NA+++++Moderate
Dean 201627+++++++++NA+++++Moderate
Dadds 201428++++++++NA+++++Low
Duffy 201429+NA++NA+NA+++High
Findling 201430+++++++++NA++++++Low
Fahmy 201331+++++++NA+++Moderate
Ghaleiha 201632+++++++++NA+NA++++++Low
Ghalichi 201633++++++NA+NA++++High
Ghanizadeh 201434+++++++++NA+++++++Low
Geier 201135+++++NA++++++High
Granpeesheh 201036++++++++NA+++++++Low
Ghaleiha 201537+++++++++NA+NA++++++Low
Ghaleiha 201338++++++++++NA+++++++Low
Ghaleiha 201339+++++++++NA+NA++++++Low
Ghaleiha 201340++++++++++NA++++++Low
Ghanizadeh 201541+++++++++NA++++++Low
Ghanizadeh 201342+++++++++NA++++++Low
Hendren 201643+++++++++NA+++++Moderate
Handen 201544, 45++++++++++NA++++++Low
Hyman 201546+++++++++NA+NA++++++Low
Handen 201147++++++++NA+NA+++++++Low
Hollander 201048+++++++++NA+++++++Low
Hardan 201249++++++++++NA++++++Low
Hasanzadeh 201250+++++++++NA+NA+++++Low
Harrison 200651, 52+++++++NA++++Moderate
Johnson 201153++++++++NA+NA++++Moderate
King 200154+++++++NA+NA+++++Moderate
Kent 201355, 56++++++++++NA++++++Low
King 201357, 58+++++++++++NA+++++++Low
Klaiman 201359+++++++++NA++++++Low
Lamberti 201660+++++++++NA++++Low
Lv 201361+NA++++NA+NA++++++High
Lemonnier 201262++++++++NA+NA+++++Moderate
Mankad 201563++++++++++NA++++++Low
McCracken 20146467++++++++++NA++++++Moderate
Mohammadi 201368+++++++++NA+NA+++++++Low
Marcus 20116975++++++++++NA+++++++Low
Munasinghe 201076++++++NA++++++Moderate
Miral 200877++++++++NA+NA+++++++Moderate
Nikvarz 201678++++++++NA++++Moderate
Navarro 201579+++++++++NA+NA+++++Low
Nikoo 201480+++++++++NA++++++Moderate
Nagaraj 200681+++++++++NA+++++Moderate
Pusponegoro 201582++++++++++++++Moderate
Pearson 201383++++++++NA+NA+++++++Low
Rezaei 201084+++++++++NA+NA+++++++Low
Rossignol 200985+++++++++++NA+++++Low
Sun 201686++NA+++++NA+++++Moderate
Sampanthavivat 201287+++++++NA+NA+++++Moderate
Shea 200488, 89++++++++NA++++++Moderate
Saad 201590++++++++NA+NA+++++Moderate
Scahill 201591+++++++++++NA+++++++Low
Shan 201592++++++NA++High
Troost 200593++++++++NA+NA++++++Low
Voigt 201494++++++++++NA+++++++Low
Van der Meer 20139598+++++++++NA+NA++++++Low
Wink 201499++NA+++++++++Moderate
Wright 2011100++++++++++NA++++++Low
Whiteley 2010101, 102+++++++++NA+++++Moderate
Wasserman 2006103+++++++++NA+++++Low
Danfors 2005104+++++++NA+NA++++++Moderate
Knivsberg 2002105_4575++++++NANA++++High

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