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Wilt TJ, Shaukat A, Shamliyan T, et al. Lactose Intolerance and Health. Rockville (MD): Agency for Healthcare Research and Quality (US); 2010 Feb. (Evidence Reports/Technology Assessments, No. 192.)
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Table 11Association between genetic polymorphism and bone fractures
| Study | Comparison | Outcome | Estimate | Mean (95% CI) |
|---|---|---|---|---|
| Gugatschka, 200791 Country: Austria Elderly male Ca++ intake difference in comparison groups: −21/Y | T/T vs. C/T | Fractures (number) | Crude mean difference | −0.03 (−0.58; 0.52) |
| T/T vs. C/C | 0.28 (−0.32; 0.88) | |||
| Obermayer-Pietsch,
200468 Country: Austria Postmenopausal women Ca++ intake difference in comparison groups: 0.55/Y | T/T vs. C/C | Bone fracture incidence | Crude OR | 0.26 (0.13; 0.54) |
| T/C vs. C/C | 0.37 (0.19; 0.71) | |||
| T/T vs. TC | 0.71 (0.39; 1.27) | |||
| Gugatschka, 200791 Country: Austria Elderly male Ca++ intake difference in comparison groups: 14/N | C/T vs. C/C | Fractures (number) | Crude mean difference | 0.31 (−0.27; 0.89) |
| Obermayer-Pietsch,
200769 Country: Austria Postmenopausal women Ca++ intake difference in comparison groups: 349/Y | T/T vs. C/C | Interim nonvertebral bone fractures | Crude OR | 0.76 (0.14; 4.06) |
| T/T vs. C/C | Interim vertebral fractures | 1.59 (0.14; 18.36) | ||
| Enattah, 200565 Country: Finland Elderly Ca++ intake difference in comparison groups: NR/NR | T/T vs. C/C | Fracture of hip | Crude OR | 0.24 (0.12; 0.46) |
| Fracture of wrist | 0.36 (0.18; 0.70) | |||
| C/T vs. C/C | Fracture of hip | 0.30 (0.17; 0.56) | ||
| Fracture of wrist | 0.43 (0.23; 0.81) | |||
| T/T vs. C/T | Fracture of hip | 0.78 (0.45; 1.36) | ||
| Fracture of wrist | 0.83 (0.49; 1.40) | |||
| Enattah, 200529 Country: Finland Postmenopausal women Ca++ intake difference in comparison groups: NR/NR | T/T vs. C/C | History of any fracture | Crude OR | 2.12 (1.05; 4.27) |
| Vertebral | 3.31 (0.40; 27.61) | |||
| Nonvertebral | 4.14 (2.06; 8.31) |
Bold = statistically significant
- Table 11, Association between genetic polymorphism and bone fractures - Lactose ...Table 11, Association between genetic polymorphism and bone fractures - Lactose Intolerance and Health
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