Table 3.13. Relative risks for breast cancer for smokers compared with nonsmokers, case-control studies

StudyNumber of casesNumber of controlsSource of controlsRelative risk (95% confidence confidence interval)
Ever smokedCurrent smokersFormer smokers
Rosenberg et al. 1984 2,160717Other cancers1.1 (0.8-1.7) * 1.1 (0.8-1.3)
Smith et al. 1984 429612Population1.2 (0.9-1.6) **
Schechter et al. 1985 123369Screening program1.4 (0.9-2.1)1.9 (1.2-3.1)1.0 (0.6-1.7)
Brinton et al. 1986b 1,5471,930Screening program1.2 (1.0-1.4)1.2 (0.9-1.4)1.2 (1.0 -1.5)
O'Connell et al. 1987 2761,519Community0.6 (0.3-1.1)§ 1.2 (0.8-1.1)
Stockwell and Lyman 1987 5,2463,921Other cancers1.3 (1.0-1.8) >§<§ 1.0 (0.8-1.3)
Adami et al. 1988 422527Population1.0 (0.8-1.3)1.1 (0.7-1.8)
Brownson et al. 1988 4561,693Screening program1.1 (0.9-1.4)1.4 (1.0-1.9)0.9 (0.6-1.2)
Kato et al. 1989 1,7408,920Other cancers0.9 (0.7-1.0)
Meara et al. 1989 998998Hospital
Ages 25-44 years1.2 (0.7-1.8)¶¶ 0.9 (0.6-1.5)
Ages 45-59 years0.8 (0.6-1.1)¶¶ 0.9 (0.7-1.3)
118118Screening program
Ages 45-69 years2.9 (1.2-7.2)¶¶ 1.0 (0.4-2.3)
Rohan and Baron 1989451451Population1.2 (0.9-1.5)1.4 (0.9-2.0)1.0 (0.7-1.5)
Schechter et al. 1989 254762Screening program
Prevalent1.1 (0.9-1.5)
Incident1.2 (0.9-1.6)
Chu et al. 1990 4,7204,682Population1.2 (1.1-1.3)1.2 (1.1-1.3)1.1 (1.0-1.3)
Ewertz 1990 1,4801,332Population0.9 (0.8-1.1)1.0 (0.8-1.2)
Palmer et al. 1991
Canada6071,214Neighborhood1.0 (0.8-1.2)1.1 (0.9-1.4)1.0 (0.7-1.3)
United States1,955805Other cancers1.2 (1.0-1.5)1.3 (1.1-1.6)1.1 (0.9-1.4)
Field et al. 1992 1,6171,617Driver's license1.0 (0.9-1.2)
Smith et al. 1994 755755Population1.0 (0.8-1.3)
Baron et al. 1996b 6,8889,529Driver's license and
Medicare
1.0 (0.9-1.1)1.1 (1.0-1.2)
Braga et al. 1996 2,5692,588Hospital0.9 (0.8-1.1)0.8 (07-1.0)1.1 (0.9-1.4)
Morabia et al. 1996 2441,032Population5.1 (2.1-12.6) ***
Gammon et al. 1998 §§§ 1,6451,497Population0.9 (0.8-1.1)0.8 (0.7-1.0)1.0 (0.8-1.2)
Millikan et al. 1998 498473HCFA¶¶¶ and state
Division of Motor
Vehicles
1.0 (0.7-1.4)1.3 (0.9-1.8)
Lash and
Aschengrau 1999
265765HCFA and next
of kin
2.0 (1.1-3.6) **** 2.3 (0.8-6.8)§§§§
Johnson et al. 2000 2,3172,438PopulationPremenopausal
women:
2.3 (1.2-4.5) ****
Premenopausal
women:
1.9 (0.9-3.8) ****
Premenopausal
women:
2.6 (1.3-5.3) ****
Postmenopausal
women:
1.5 (1.0-2.3) ****
Postmenopausal
women:
1.6 (1.0-2.5) ****
Postmenopausal
women:
1.4 (0.9-2.1) ****
*

> 25 cigarettes/day.

**

Continuous smokers.

§

>20 cigarettes/day.

>§<§

>40 cigarettes/day.

>20 cigarettes/day.

¶¶

>5 cigarettes/day.

***

> 20 cigarettes/day; reference group comprised of subjects not exposed to active or passive smoking.

§§§

Women <45 years of age.

¶¶¶

HCFA = Health Care Financing Administration.

****

Compared with subjects not exposed to active or passive smoking.

§§§§

Persons smoking within 5 years before diagnosis.

From: Chapter 3. Health Consequences of Tobacco Use Among Women

Cover of Women and Smoking
Women and Smoking: A Report of the Surgeon General.
Office on Smoking and Health (US).

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