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Pillay J, Boylan K, Carrey N, et al. First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2017 Mar. (Comparative Effectiveness Reviews, No. 184.)

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First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update [Internet].

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Figure 79 displays a meta-graph of studies reporting the mean difference of SGAs versus placebo for global impressions of severity using Tourette’s Syndrome CGI-S in tic disorders. Our meta-graph showed that both Aripiprazole (1 trial, 61 subjects; MD, −0.60; 95% CI, −1.19 to −0.01) reduced severity relative to placebo. For Ziprasidone (1 trial, 28 subjects; MD, −0.70; 95%CI, −1.42 to 0.02) there was no statistically significant difference between groups.

Figure 79SGAs versus placebo for global impressions of severity using Tourette’s Syndrome CGI-S in tic disorders

CGI-S = Clinical Global Impressions of Severity; SD = standard deviation; SGA = second-generation antipsychotic

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