CytokineSource of cytokineCytokine receptorBiologic effects of cytokine
TNF-alphaMacrophages, FLS, Endothelial cellsTNFRSF1, TNFRSF2

FLS activation and proliferation, resulting in pannus, activation of chondrocytes, osteoclasts, and endothelial cells.

IFN-gammaT cells, NK cells, Macrophages, B cells, Dendritic cellsIFNGR1, IFNGR2Activation of antigen-presenting cells by upregulating MHC Class II genes.
IL-1Macrophages, FLS, ChondrocytesIL-1R1, IL-1R2Activates FLS, macrophages, neutrophils, T and B cells, osteoclasts, and chondrocytes, promoting TNF-alpha and IL-6 production, PGE2 production, and production of MMPs.
 IL-6Macrophages, FLS, T cells, endothelial cellsHeterodimer of IL-6R-alpha and gp 130 B cell activation and differentiation, Th17 activation and differentiation, osteoclast formation, and stimulates the liver to synthesize acute phase proteins.
 IL-15 Macrophages, Dendritic cells, endothelial cells, FLS Heterotrimer of IL-15R-alpha, IL-15R-beta, and gamma-cChemotactic and activation factor for T cells induces the production of TNF-alpha, MMP, MCP-1, and IL-8.
IL-17Th17 cells, ILC3Hertodimer of IL-17RA and IL-17RB, IL-17C, or IL-17EActivates and attracts T cells and neutrophils, activates FLS, macrophages, endothelial cells, osteoclasts, and chondrocytes, stimulates the production of TNF-alpha, IL1-beta, IL-6, IL-8, IL-23, chemokines, nitric oxide (NO), PG, GM-CSF, MMPs, promotes RANKL
IL-18Macrophages, Dendritic cells, FLSHeterodimer of IL-18R-alpha and IL-18R-betaStimulates macrophages, T cells, and NK cells to produce TNF-alpha, IL-1-beta, and GM-CSF, which activates neutrophils.
IL-23Macrophages, Dendritic cells, B cellsHeterodimer of IL-23R and IL-23R and IL-12R-beta-1Induces differentiation of Th17 cells and osteoclasts, production of IL-6, TNF-alpha, IL-1-beta, and chemokines.
IL-8 (Chemokine CXCL8) Macrophages, FLS, endothelial cellsCXCR1, CXCR2Chemotactic and activation factors for neutrophils, T cells, and NK cells.
Other chemokines in the CXC and CC familiesNeutrophils, Macrophages, FLS, T cells, etc.Various CXC and CC receptorsAttracts and promotes activation of neutrophils, macrophages, T cells, FLS, etc. 

From: Rheumatoid Arthritis

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