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Mepolizumab (Nucala) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 Nov.

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Mepolizumab (Nucala) [Internet].

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Pharmacoeconomic Review Report

Drugmepolizumab (Nucala)
IndicationFor the add-on maintenance treatment of adult patients with severe eosinophilic asthma who:

are inadequately controlled with high-dose inhaled corticosteroids and an additional asthma controller(s) (e.g., LABA), and

have a blood eosinophil count of ≥ 150 cells/mcL (0.15 GI/L) at initiation of treatment with mepolizumab OR ≥ 300 cells/mcL (0.3 GI/L) in the past 12 months.

Reimbursement requestFor the treatment of adult patients (≥ 18 years) with severe eosinophilic asthma (≥ 150 cells/mcL at treatment initiation or ≥ 300 cells/mcL in past 12 months) whose symptoms are inadequately controlled with high-dose inhaled corticosteroids and an additional asthma controller(s), and who have either experienced ≥ 2 exacerbations in the past 12 months or have dependency on systemic corticosteroids.
Dosage form(s)Lyophilized powder for subcutaneous injection, 100 mg/mL
NOC date3 December 2015
ManufacturerGlaxoSmithKline Inc.

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Copyright © CADTH 2016.

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Bookshelf ID: NBK409872

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