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Some Thyrotropic Agents
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 79
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.
This volume evaluates carcinogenicity to humans of 19 chemicals that are carcinogenic to the thyroid follicular-cell epithelium in rodents. These included some so-called 'anti-thyroid' drugs (methimazole, methylthiouracil, propylthiouracil and thiouracil); some sedatives (doxylamine succinate and phenobarbital); and some other drugs including the systemic antifungal antibiotic griseofulvin, the diuretic spironolactone, and the antibacterial sulfa drugs sulfamethazine and sulfamethoxazole. Other chemicals are or have been used in agriculture as pesticides (amitrole, chlordane/heptachlor, hexachlo-robenzene and toxaphene), in foods and cosmetics (kojic acid), in hair dyes (2,4-diaminoanisole) or as industrial chemicals (N,N'-diethylthiourea, ethylenethiourea and thiourea).
Contents
- NOTE TO THE READER
- LIST OF PARTICIPANTS
- PREAMBLE
- GENERAL REMARKS ON THE SUBSTANCES CONSIDERED
- THE MONOGRAPHS
- DRUGS
- ANTI-THYROID DRUGS
- SEDATIVES
- ANTIFUNGAL AGENT: GRISEOFULVIN
- DIURETIC: SPIRONOLACTONE
- ANTIBACTERIAL AGENTS
- PESTICIDES
- AMITROLE
- CHLORDANE AND HEPTACHLOR
- HEXACHLOROBENZENE
- TOXAPHENE
- FOOD AND COSMETICS AGENT: KOJIC ACID
- HAIR DYE: 2,4-DIAMINOANISOLE AND ITS SALTS
- INDUSTRIAL CHEMICALS
- N,N′-DIETHYLTHIOUREA
- ETHYLENETHIOUREA
- THIOUREA
- DRUGS
- SUMMARY OF FINAL EVALUATIONS
- SUPPLEMENTARY CORRIGENDA TO VOLUMES 1–78
Corrigenda to the IARC Monographs are published online at http://monographs.iarc.fr/ENG/Publications/corrigenda.php.
Corrigenda to Volume 79. (PDF, 64K)
LIBRARY CATALOGUING DATA
This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 10–17 October 2000
Lyon, France - 2001
IARC MONOGRAPHS
In 1969, the International Agency for Research on Cancer (IARC) initiated a programme on the evaluation of the carcinogenic risk of chemicals to humans involving the production of critically evaluated monographs on individual chemicals. The programme was subsequently expanded to include evaluations of carcinogenic risks associated with exposures to complex mixtures, life-style factors and biological and physical agents, as well as those in specific occupations.
The objective of the programme is to elaborate and publish in the form of monographs critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations; to evaluate these data in terms of human risk with the help of international working groups of experts in chemical carcinogenesis and related fields; and to indicate where additional research efforts are needed.
The lists of IARC evaluations are regularly updated and are available on Internet: http://monographs.iarc.fr/
This project was supported by Cooperative Agreement 5 UO1 CA33193 awarded by the United States National Cancer Institute, Department of Health and Human Services. Additional support has been provided since 1986 by the European Commission, since 1993 by the United States National Institute of Environmental Health Sciences and since 1995 by the United States Environmental Protection Agency through Cooperative Agreement Assistance CR 824264.
- ©International Agency for Research on Cancer, 2001
- Distributed by IARCPress (Fax: +33 4 72 73 83 02; E-mail: rf.crai@sserp) and by the World Health Organization Marketing and Dissemination, 1211 Geneva 27 (Fax: +41 22 791 4857; E-mail: tni.ohw@snoitacilbup)
- Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention.
- All rights reserved. Application for rights of reproduction or translation, in part or in toto, should be made to the International Agency for Research on Cancer.
IARC Library Cataloguing in Publication Data
Some thyrotropic agents /
- IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2001 : Lyon, France)
- (IARC monographs on the evaluation of carcinogenic risks to humans; 79)
- 1. Carcinogens – congresses 2. Thyroid Carcinogens – congresses I. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans II. Series
- ISBN 92 832 1279 7 (NLM Classification: W1)
- ISSN 1017-1606
- PRINTED IN FRANCE
- NLM CatalogRelated NLM Catalog Entries
- Review Fetal and neonatal toxicity of drugs.[Can Med Assoc J. 1968]Review Fetal and neonatal toxicity of drugs.Yaffe SJ. Can Med Assoc J. 1968 Feb 10; 98(6):301-6.
- Thionamides and analogues: a reapraisal of antithyroid and thyroid carcinogenic effects.[Med Hypotheses. 1980]Thionamides and analogues: a reapraisal of antithyroid and thyroid carcinogenic effects.Spencer RP, Hosain H. Med Hypotheses. 1980 Feb; 6(2):199-205.
- [Diagnostic indications on phototoxic and photoallergic skin changes].[Hautarzt. 1975][Diagnostic indications on phototoxic and photoallergic skin changes].Ippen H. Hautarzt. 1975 Feb; 26(2):77-8.
- [Harmful effects of common drugs on the visual apparatus. Diuretics].[Bull Soc Belge Ophtalmol. 1972][Harmful effects of common drugs on the visual apparatus. Diuretics].Watillon M, Robe-Vanwyck A. Bull Soc Belge Ophtalmol. 1972; 160(1):215-37.
- Review The use of drugs in the patient with uremia.[Mod Treat. 1969]Review The use of drugs in the patient with uremia.Hollenberg NK, Epstein M. Mod Treat. 1969 Sep; 6(5):1011-35.
- Some Thyrotropic AgentsSome Thyrotropic Agents
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