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Vaidya JS, Wenz F, Bulsara M, et al. An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial). Southampton (UK): NIHR Journals Library; 2016 Sep. (Health Technology Assessment, No. 20.73.)

Cover of An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial)

An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial).

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Appendix 3List of presentations

The TARGIT website [see www.targit.org.uk (accessed 7 July 2016)] has a wealth of information about the TARGIT technique and the TARGIT trials.

DateInvited presentation title and meeting
2 March 1997Multicentricity of breast cancer: new findings and their clinical and biological implications (15 minutes)
1st Annual Meeting of the Indian Breast Group at Tata Memorial Hospital, Mumbai, India
2 March 1998Local recurrence has nothing to do with residual disease (20 minutes)
Biennial Presidential Conference of the British Oncological Association, Royal Society of Medicine, London, UK
19 September 1998Radiosurgery: a novel method of treatment of early breast cancer (15 minutes)
International Meeting on Whole-Body Stereotactic Radiotherapy, Edinburgh, UK
13 November 1998Radiosurgery: a novel method of treatment of early breast cancer (15 minutes)
North London Cancer Network Breast Cancer Tumour Board Away Day, Royal Society of Arts, London, UK
18 February 1999Novel radiotherapy techniques at the Middlesex hospital (45 minutes)
Meyerstein Institute of Oncology Seminar, London, UK
22 June 1999Radiosurgery: an innovative approach to management of early breast cancer (45 minutes)
Surgical Forum, Department of Surgery, Norfolk and Norwich University Hospital, Norwich, UK
7 September 1999Radiosurgery: an innovative approach to local treatment of breast cancer (1 hour)
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
8 September 1999Radiosurgery: an innovative approach to local treatment of breast cancer (1 hour)
Cleveland Clinic, Cleveland, OH, USA
13 September 1999Radiosurgery: an innovative approach to local treatment of breast cancer (1 hour)
Our Lady of Mercy Medical School, New York, NY, USA
18 February 2000Breast conservative therapy – novel approaches – targeted Intraoperative radiotherapy (20 minutes)
Breast Cancer in the New Millennium, Nagpur, India
1–2 December 2000Rethinking cancer research – discussion
‘Blue-Skying’ the Future of Cancer Research, Cambridge, UK
9 December 2000TARGIT – a novel approach to local treatment of breast cancer (30 minutes)
23rd Annual San Antonio Breast Cancer Conference (Satellite Symposium), San Antonio, TX, USA
31 January 2001Targeted intraoperative radiotherapy for breast cancer – a randomised trial (20 minutes)
International Conference of Radiation Oncology (ICRO) (Satellite Symposium), Melbourne, VIC Australia
27 February 2002Intraoperative radiotherapy for breast cancer (20 minutes)
Breakthrough Breast Cancer, London, UK
8 March 2002Intraoperative radiotherapy for breast cancer – the UK experience
8th Annual Clinical Oncology Symposium: Current Concepts and Developments in Intraoperative Radiation Oncology, New York, NY, USA
20 March 2002Targeted intraoperative radiotherapy – rationale, technique and results (30 minutes)
3rd European Breast Cancer Conference, Barcelona, Spain
17 May 2002Targeted Intraoperative radiotherapy – rationale, technique and results
Congress of the Portuguese Society of Radiology and Radiotherapy, Algarve, Portugal
22 May 2002Targeted intraoperative radiotherapy for early breast cancer – a randomised trial
American Brachytherapy Society meeting, Orlando, FL, USA
5 June 2002Targeted intraoperative radiotherapy – a randomised trial (30 minutes)
4th Milan Breast Cancer Conference, Milan, Italy
17 June 2002TARGIT
5th meeting of UK clinical triallists, Birmingham, UK
25 September 2002Supervision of first two cases of intraoperative radiotherapy for breast cancer using INTRABEAM and lecture (1 hour)
CRO (National Cancer Institute), Aviano, Italy
5 November 2002Intraoperative radiotherapy for breast cancer
Symposium on Novel Treatments for Breast Cancer, Empoli, Italy
13 March 2003Update on cosmetic outcome of TARGIT
8th International Conference: Primary Therapy of Early Breast Cancer (Satellite Symposium on Intraoperative Radiotherapy), St Gallen, Switzerland
6 June 2003TARGIT – targeted Intraoperative radiotherapy for breast cancer (30 minutes)
5th Milan Breast Cancer Conference, Milan, Italy
19 August 2003Targeted intraoperative radiotherapy, its rationale, technique and trials (45 minutes)
MD Anderson Cancer Center, Houston, TX, USA
4 December 2003Intraoperative radiotherapy for breast cancer (TARGIT) (30 minutes) – webcast [PowerPoint® (Microsoft Corporation, Redmond, WA, USA)]
26th Annual Breast Cancer Conference, San Antonio, TX, USA
9 December 2003The novel approach of targeted intraoperative radiotherapy for breast cancer (45 minutes)
Memorial Sloan Kettering Cancer Center, New York, NY, USA
9 December 2003The novel approach of targeted intraoperative radiotherapy for breast cancer (45 minutes)
New York Presbyterian Hospital, Cornell Institute, New York, NY, USA
3 February 2004Intraoperative radiotherapy for breast cancer (TARGIT)
Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
18 Jun 2004Updated results of TARGIT (15 minutes)
6th Milan Breast Cancer Conference, Milan, Italy
19 November 2004Intraoperative radiotherapy for breast cancer
Annual Meeting of the Scottish Radiological Society, Dundee, UK
26 November 2004Intraoperative radiotherapy for breast cancer
Focus on Innovative and Locoregional Treatments – VII Congresso Nazionale SITILO (Societa’ Italiana di Terapie Integrate Locoregionali in Oncologia), Florence, Italy
7 December 2004TARGIT meeting with surgeons and radiation oncologists
New Orleans, LA, USA
21 December 2004The international TARGIT trial
1st Workshop on the Health Technology Assessment Programme for Italy (Programma Ricerca e Innovazione Emilia-Romagna – 1° Workshop – La radiotherapia intraoperatoria nel tumore della mammella), Bologna, Italy
25 February 2005Targeted intraoperative radiotherapy trial
Scottish Cancer Triallists Meeting, St Andrews, UK
1 November 2005Debate on partial breast irradiation in selected patients and accurate targeting of boost in others: rationale for partial breast irradiation in selected patients (15 minutes)
13th European Cancer Conference (ECCO-13), Paris, France
17 December 2005Intraoperative radiotherapy for breast cancer (20 minutes)
3rd European Conference on Plastic and Reconstructive Surgery of the Breast, Milan, Italy
10 March 2006Targeted intraoperative radiotherapy trial
Breast Cancer Triallists Meeting, Dundee, UK
24 June 2006The indications for TARGIT (20 minutes)
8th Milan Breast Cancer Conference, Milan, Italy
14 March 2007Targeted intraoperative radiotherapy – rationale, technique and clinical trials (30 minutes)
10th International Conference on Primary Therapy of Early Breast Cancer (Satellite Symposium), St Gallen, Switzerland
18 April 2007Breast conserving surgery – TARGIT for the 21st century and related translational research (40 minutes)
Cambridge International Conference on Breast Screening, Cambridge, UK
15 September 2007Cutting edge techniques at the forefront of breast surgery (40 minutes)
Delegates: about 100 surgeons from 17 countries (14–16 September 2007), Conrad Dublin, Dublin, Ireland
19 September 2007The TARGIT trials – alone and as a boost (1 hour)
Nottingham International Breast Cancer Conference (Satellite Symposium), Nottingham, UK
6 December 2007Round table discussion between cancer specialists in the UK along with the Minister for Health, the Cancer Czar, Chairman of the National Cancer Research Network (NCRN) and the All Party Chairman On Cancer Care
House of Commons, London, UK
20 December 2007Breast conserving surgery – TARGIT for the 21st century (1 hour)
Goa Medical College Staff Society Meeting, Goa, India
12 April 2008Individualised treatment for breast cancer: TARGIT for the 21st century
Indian Breast Cancer Initiative, New Delhi, India
12 April 2008Demonstration of operative technique: targeted intraoperative radiotherapy for breast cancer
Indian Breast Cancer Initiative, New Delhi, India
29 May 2008An update of the novel approach to local treatment of breast cancer using intraoperative radiotherapy
Radiation Medicine Program, RMP Special Lecture, Radiation Physics Department, University Health Network, Princess Margaret Hospital, Toronto, ON, Canada
2 June 2008TARGIT Satellite Meeting (30 minutes)
ASCO Satellite, Chicago, IL, USA
27 June 2008TARGIT German user group meeting (30 minutes)
University of Mannheim, Mannheim, Germany
13 January 2009The TARGIT trial
Institute Curie, Paris, France
16 January 2009The TARGIT trial
Sheffield Cancer Network, Sheffield, UK
12 March 2009Targeted intraoperative radiotherapy – update of the randomised trial (20 minutes)
11th International Conference on Primary Therapy of Early Breast Cancer (Satellite Symposium), St Gallen, Switzerland
8 May 2009Individualising breast cancer treatment – TARGIT for the 21st century
Lincoln, UK
11 June 2009TARGIT trial – progress
UK Breast Intergroup, Birmingham, UK
3 September 2009Targeted intraoperative radiotherapy – the clinical trials
Copenhagen, Denmark
23 October 2009Targeted Intraoperative radiotherapy
All India Institute of Medical Sciences, Army Medical Referral and Research Centre, New Delhi, India
29 October 2009Targeted intraoperative radiotherapy
Tata Memorial Hospital, Mumbai, India
30 October 2009Demonstration of two surgical operations with the TARGIT procedure
Indo-American Cancer Centre and Research Institute, Hyderabad, India
7 November 2009Innovations and progress in breast cancer treatment (unable to take up)
Innaugural conference, Institute of Breast Cancer, Saifee Hospital, Mumbai India
25 March 2010TARGIT trials: a 15-year evolution
TARGIT Satellite Meeting, European Breast Cancer Conference, Barcelona, Spain
30 April 2010Intraoperative radiotherapy (TARGIT trials) (plenary)
American Brachytherapy Society Meeting, Atlanta, GA, USA
6 June 2010First results of the TARGIT-A trial: safety and efficacy of targeted intraoperative radiotherapy vs. external beam radiotherapy results with a 10-year maximum follow up
TARGIT Symposium at the ASCO Meeting, Chicago, IL, USA
9 June 2010First results of the TARGIT-A trial: safety and efficacy of targeted intraoperative radiotherapy vs. external beam radiotherapy results with a 10-year maximum follow up
University of Louisville, KY, USA and University of Indianapolis, IN, USA
10 June 2010First results of the TARGIT-A trial: safety and efficacy of targeted intraoperative radiotherapy vs. external beam radiotherapy results with a 10-year maximum follow up
Cleveland Clinic, Cleveland, OH, USA
18 June 2010First results of the TARGIT-A trial: safety and efficacy of targeted intraoperative radiotherapy vs. external beam radiotherapy results with a 10-year maximum follow up
TARGIT Symposium, Milan Breast Cancer Conference, Milan, Italy
16 September 2010Targit-A trial: the results at the end of 10 years maximum follow up and TARGIT-B trial: targeted intra-operative radiotherapy boost – a randomised trial for young and high risk patients including those after post-neoadjuvant systemic therapy lumpectomy (30 minutes)
European Society of Surgical Oncology, Bordeaux, France
16 September 2010Targit-A trial- the results at the end of 10 years maximum follow up (15 minutes) [plenary – given via Skype™ (Microsoft Corporation, Redmond, WA, USA)]
British Breast Cancer Research Conference, Nottingham, UK
16 September 2010Workshop on New Technologies – Intraoperative Radiotherapy (30 minutes) (could not take up)
British Breast Cancer Research Conference, Nottingham, UK
22 September 2010TARGIT for the 21st century (30 minutes)
Annual South West England breast screening education day, Taunton Racecourse, Taunton, Exeter
23 September 2010TARGIT-A trial results
Weekly meetings of the Institute of Womens’ Health, University College London, London, UK
7 October 2010TARGIT-A trial results – lecture followed by panel discussion (25 minutes)
University College London Partners and North London Cancer Network Breast Cancer Away Day, RIBA, London, UK
12 November 2010TARGIT-A trial results, TARGIT-Boost trial and implications for India
Tata Memorial Hospital, Mumbai, India, and Raheja Hospital, Mumbai, India
13 November 2010Plenary: TARGIT-A trial and TARGIT-Boost trial and implications for India; Panel discussion: screening for breast cancer in India
New India Cancer Charity Initiative Brinker Awardee Symposium, New Delhi, India
14 November 2010TARGIT-A trial results, TARGIT-Boost trial and implications for India
Apollo Hospital, New Delhi, India
26 February 2011The evolution of TARGIT
National Undergraduate Medical Students Conference, University College London, London, UK
17 March 2011TARGIT-A trial – 1 year on
St Gallen Breast Cancer Conference (Satellite Symposium), Switzerland
29 April 2011Intraoperative radiotherapy (plenary)
American Society of Breast Surgeons, Washington, DC, USA
7 May 2011Oxford style debate on intraoperative radiotherapy as a boost (plenary debate)
International Society of Intraoperative Radiotherapy (ISIORT) and ESTRO, London
12/13 May 2011Demonstration of technique of TARGIT; TARGIT-A trial results and TARGIT-B trial
University of Padua Medical School, Padua, Italy
17 June 2011TARGIT-A and TARGIT-Boost trials and implications for India
Medicity Hospital, New Delhi, India
18 June 2011TARGIT-A and TARGIT-Boost trials and implications for India
Association of Radiation Oncologists in India (AROI) (Tamilnadu and Pondicherry Chapter), Chennai, India
19 June 2011TARGIT-A and TARGIT-Boost trials and implications for India
Bangalore Oncology Group Meeting, Bangalore, India
30 June 2011TARGIT-A trial results
2nd UK National Breast Cancer Meeting, King’s Fund, London, UK
1 July 2011TARGIT trials and training day
User group and training meeting, University of Mannheim, Mannheim, Germany
28 August 2011Main speaker, Swedish Surgical Society’s Annual Surgical Week
Karolinska Institute, Sweden
3 September 2011Keynote address (30 minutes): Original research: evolution of TARGIT; Screening, MRI, and skin sparing mastectomy (15 minutes)
Breast Cancer CME and Symposium, 1st West Zone CME Programme, Association of Breast Surgeons of India, Pune, India
7 November 2011Targeted intraoperative radiotherapy for breast cancer (TARGIT) (plenary)
British Association of Surgical Oncology – Association of Cancer Surgeons (BASO-ACS) Scientific Conference, Royal College of Surgeons of England, London [see www​.baso.org/conferences​/past-conferences​/baso-∼-acs-scientific-conference-nov-2011.aspx (accessed 18 July 2016)]
29 December 2011Keynote address: TARGIT – intraoperative radiotherapy to the breast (unable to take up)
71st Annual Conference of the Association of Surgeons of India (ASICON), Kochi, India
23 February 2012New models of radiotherapy. Cutting-edge cancer treatments: expense and expectation?
An Independent Cancer Patients’ Voice workshop, CRUK London Research Institute, London, UK
27 February 2012TARGIT trials update
Breast Tumour Away Day, North London Cancer Network, London, UK
15 March 2012Intraoperative radiotherapy vs. whole breast radiotherapy (plenary – given via Skype)
9th Annual Miami Breast Cancer Conference, Miami, FL, USA
18 May 2012IORT – who, when and how: TARGIT for India (plenary – remotely with audience participation)
1st Annual Conference of the Association of Breast Surgeons of India International Congress, Hyderabad, India
9 June 2012Update on targeted radiotherapy
9th Düsseldorf Breast Cancer Conference, Düsseldorf, Germany
13 June 2012Expert advisor, Medical Technologies Advisory Committee meeting
NICE, London, UK
29 June 2012TARGIT trials – surgical aspects and trial update
University of Mannheim, Mannheim, Germany
12 August 2012Felicitation and lifetime achievement award lecture
Centenary Celebrations of the Gomant Vidya Niketan, Goa, India
13 September 2012Invited speaker: intraoperative radiotherapy: results from the randomised trial
ASCO Breast Symposium, San Francisco, CA, USA
10/11 October 2012Visiting Professorship, Morris Deutsch Memorial Lectureship Dinner and Grand Rounds
Johns Hopkins Hospital, Baltimore, MD, USA
19 October 2012TARGIT-A and TARGIT-B trials
Master’s course – seminar on intraoperative radiotherapy, Madrid, Spain
30 November 2012, will present RemotelySurgery in breast cancer: does ‘less mean more?’
Patient First – Joint International Conference, Sri Balaji Vidhyapeeth, Pondicherry, India, and the Royal College of Physicians and Surgeons, Glasgow, UK
2 February 2013Main speaker: TARGIT trials in breast cancer
New York Metropolitan Breast Cancer Group (NYMBCG) 40th Annual Symposium, New York Academy of Medicine, NY, USA
13/14 April 2013Guest plenary lecture: Breast conservation: emerging trends and future directions
Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
13 June 2013TARGIT – update *Highlight*
7th INTRABEAM user meeting, Mannheim, Germany
19 September 2013TARGIT trials
Clinicians from University of Miami, Miami, FL, USA
20 September 2013TARGIT trials
Ashikari Breast Center, Dobbs Ferry, NY, USA
21 September 2013TARGIT trials
Satellite meeting at ASTRO and Emory University, Atlanta, GA, USA
2 October 2013Controversies in management of breast cancer: the evolution of the TARGIT treatment
Divisional Away Day, University College London, London, UK
4 October 2013TARGIT trials
Journées Franco-Brésiliennes de Cancérologie Mammaire: Mise à Jour sur le Cancer du Sein – Updating on Breast Cancer, Strasbourg, France
24 October 2013Intraoperative technique – one stop shopping – what could be better? (25 minutes)
American Brachytherapy Society School of Breast Brachytherapy, Las Vegas, NV, USA
25 October 2013Debate – IORT vs. APBI (1 hour)
American Brachytherapy Society School of Breast Brachytherapy, Las Vegas, NV, USA
9 January 2014Developing evidence for new devices in clinical practice with randomised trials
UCL French Embassy Science and Technology Workshop, Nanomaterials for Biomedical Applications, London, UK
7 February 2014Results of the TARGIT-A trial
4th International Breast Disease Centres Congress, Paris, France
6 May 2014The TARGIT-A and TARGIT-B trials (45 minutes)
Sírio Libanês Hospital, São Paulo, Brazil
7 May 2014The TARGIT-A and TARGIT-B trials (30 minutes)
Brazilian National Cancer Hospital, with remote connection to the Cancer Hospital in Fortaleza and Oswaldo Cruz Hospital in Recife, Brazil
8 May 2014The TARGIT-A and TARGIT-B trials (30 minutes, plenary)
2nd International Breast Symposium, Salvador, Brazil
11 October 2014The TARGIT-A and TARGIT-B trials
International Conference on Advances in Breast Cancer, Goa, India
31 October 2014The TARGIT-A and TARGIT-B trials
ESSO-34 European Society of Surgical Oncology and British Association of Surgical Oncology Joint Conference, Liverpool UK
12 November 2014The TARGIT-A and TARGIT-B trials
Breast Educational Day, Oxford, UK
9 December 2014The TARGIT-A trial results
NICE, London, UK
10 February 2015Oxford-style debate: the TARGIT-A trial results
Royal College of Radiologists, London, UK
27 April 2015The TARGIT-A trial results – it is safe to not irradiate rest of the breast
ESTRO Forum, Barcelona, Spain
7 May 2015The TARGIT-A and TARGIT-B trials
Mount Carmel Hospital West, Columbus OH, USA
7 May 2015The TARGIT-A and TARGIT-B trials
William Beaumont Hospital, Michigan OH, USA
9 May 2015The TARGIT-A and TARGIT-B trials
Advances in Brachytherapy Symposium, Weill Cornell Medical Center, New York, NY, USA
16 May 2015The TARGIT-A and TARGIT-B trials [via FaceTime (Apple Inc., Cupertino, CA, USA)]
4th MAYMET SENATURK Meeting on Value Based Quality in Breast Care, Kusadasi, Aydin, Turkey
9–10 July 2015Keynote lecture on the TARGIT trials, chairing of sessions
9th Intrabeam System User Meeting, Manheimm, Germany
26 August 2015Expert opinion (no presentation)
INTRABEAM appraisal by NICE, London, UK

APBI, Accelerated Partial Breast Irradiation; CME, Continuing Medical Education.

Late-breaking proffered papers

DatePresentation title and meeting
1 November 2010Targeted intraoperative radiotherapy (TARGIT) vs. whole breast external beam radiotherapy (EBRT) by ASTRO risk categories: late-breaking abstract (oral presentation in the plenary hall)
52nd Annual meeting of ASTRO, San Diego, CA, USA
6 December 2012Targeted intraoperative radiotherapy for early breast cancer: TARGIT-A trial – updated analysis of local recurrence and first analysis of survival (oral presentation in the plenary hall)
35th San Antonio Breast Cancer Symposium, San Antonio, TX, USA
Copyright © Queen’s Printer and Controller of HMSO 2016. This work was produced by Vaidya et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

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Bookshelf ID: NBK390276
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