FIGURE 10. Cumulative hazard of developing breast cancer in 480 BRCA1 mutation carriers, by risk group (overall breast cancer risk score split into quintiles), based on the three validated SNPs from Antoniou et al.

FIGURE 10

Cumulative hazard of developing breast cancer in 480 BRCA1 mutation carriers, by risk group (overall breast cancer risk score split into quintiles), based on the three validated SNPs from Antoniou et al.136 and the six SNPs from Turnbull et al.131 that have not yet been validated in BRCA1 mutation carriers. Source: reproduced with permission from Ingham SL, Warwick J, Byers H, Lalloo F, Newman WG, Evans DGR. Is multiple SNP testing in BRCA2 and BRCA1 female carriers ready for use in clinical practice? Results from a large Genetic Centre in the UK. Clinical Genetics 2013, 84:1, 37–42, © 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.140

From: Chapter 3, Project 2: assessment of predictive value of new genetic variants

Cover of Improvement in risk prediction, early detection and prevention of breast cancer in the NHS Breast Screening Programme and family history clinics: a dual cohort study
Improvement in risk prediction, early detection and prevention of breast cancer in the NHS Breast Screening Programme and family history clinics: a dual cohort study.
Programme Grants for Applied Research, No. 4.11.
Evans DG, Astley S, Stavrinos P, et al.
Southampton (UK): NIHR Journals Library; 2016 Aug.
Copyright © Queen’s Printer and Controller of HMSO 2016. This work was produced by Evans et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.