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van den Heuvel-Eibrink MM, editor. Wilms Tumor [Internet]. Brisbane (AU): Codon Publications; 2016 Mar. doi: 10.15586/codon.wt.2016.ch16
WT1 expression after conventional chemotherapy
| Authors | MRD (cutoff) | LOG reduction | Time of assessment | Main results |
|---|---|---|---|---|
| Weisser et al. (16)* | 0.4% | </≥2 Log | 16–60 vs 61–120 vs 121–180 days after start of therapy | Within 61–120 and 121–180 days, levels ≤0.4%, and ≥2 log reduction were associated with improved EFS and OS |
| Cilloni et al. (9)* | 250 × 104 ABL copies | </≥ 2 Log | Postinduction/postconsolidation | WT1 transcript reduction ≥2 log after induction, and WT1 levels more than 250 × 104 ABL copies after consolidation predicted a significantly increased risk of relapse |
| Nomdedeu et al. (13)* | 170 and 100× 104 ABL copies | - | Postinduction/postintensification | WT1 levels greater than 170 copies after induction and 100 copies after intensification identified patients with the highest probability to relapse and die |
| Lapillone et al. (29)† | 50 × 104 ABL copies | - | Postinduction | WT1 > 50× 104 ABL copies after induction is an independent prognostic risk factor of relapse and death |
| Rossi et al. (38)* | 77 × 104 ABL copies | </≥ 1.96Log | Postinduction/postconsolidation | Only postinduction MRD ≥ 77× 104 ABL copies and log reduction ≤1.96 predicted a shorter DFS and OS |
Study performed on adults.
Study performed on children.
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