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van den Heuvel-Eibrink MM, editor. Wilms Tumor [Internet]. Brisbane (AU): Codon Publications; 2016 Mar. doi: 10.15586/codon.wt.2016.ch13
Working model of the regulation of WT1 and its target genes. The expression of WT1 is activated during embryonic development and in the adult heart after injury. Upregulation of WT1 is caused by hypoxia, growth factors, and inflammation. WT1 in turn is able to activate multiple genes that are important for the regulation of different processes, including EMT, angiogenesis, remodeling of the ECM.
From: Chapter 13, WT1 in Cardiac Development and Disease
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