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van den Heuvel-Eibrink MM, editor. Wilms Tumor [Internet]. Brisbane (AU): Codon Publications; 2016 Mar. doi: 10.15586/codon.wt.2016.ch13
Expression of WT1 and the fate of epicardial cells. (a) The epicardium arises from the proepicardium. A subset of cells undergo EMT and migrate into the subepicardium and myocardium. WT1 (green) is expressed by cells in the proepicardium, epicardium, EPDC, endothelial cells, and endocardial cells. (b) EPDCs contribute to the formation of fibroblasts, smooth muscle cells and endothelial cells; the contribution to cardiomyocytes and endocardial cells is controversial. Cardiac fibroblasts can be subdivided into interstitial fibroblasts, perivascular fibroblast, and valvular interstitial cells.
From: Chapter 13, WT1 in Cardiac Development and Disease
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