Structured Abstract

Contents

• Preface
• Acknowledgments
• Key Informants
• Technical Expert Panel
• Peer Reviewers
• Executive Summary
• Introduction
  • Background
  • Scope and Key Questions
  • Organization of This Report
• Methods
  • Criteria for Inclusion/Exclusion of Studies in the Review
  • Searching for the Evidence
  • Data Abstraction and Data Management
  • Assessment of Methodological Risk of Bias of Individual Studies
  • Data Synthesis/Analysis
  • Grading the Strength of the Body of Evidence for Each Key Question
  • Applicability
  • Peer Review and Public Commentary
• Results
  • Introduction
  • Results of Literature Searches
  • Key Questions 1a–c Acute Gout Treatment
  • Key Question 2 Dietary and Lifestyle Management of Gout
  • Key Question 3 Pharmacologic Management of Hyperuricemia in Gout Patients
  • Key Question 4 Treatment Monitoring of Patients with Gout
  • Key Question 5 Discontinuation of Pharmaceutical Management for Patients on Acute or Chronic Gout Medications
• Discussion
  • Key Findings and SoE
  • Findings in Relationship to What is Already Known
  • Applicability
  • Implications for Clinical and Policy Decisionmaking
  • Limitations of the Comparative Effectiveness Review Process
  • Limitations of the Evidence Base
  • Research Gaps
  • Conclusions
• References
• Abbreviations/Acronyms
• Appendix A Search Strategy
• Appendix B List of Excluded Studies

Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services¹, . Contract No. 290-2012-00006-I Prepared by: RAND Southern California Evidence-Based Practice Center, Santa Monica, CA

Suggested citation:

Shekelle PG, FitzGerald J, Newberry SJ, Motala A, O'Hanlon CE, Okunogbe A, Tariq A, Han D, Dudley W, Shanman R, Booth M. Management of Gout. Comparative Effectiveness Review No. 176. (Prepared by the RAND Southern California Evidence-based Practice Center under Contract No. 290-2012-00006-I.) AHRQ Publication No.16-EHC017-EF. Rockville, MD: Agency for Healthcare Research and Quality; March 2016. www.effectivehealthcare.ahrq.gov/reports/final.cfm.

This report is based on research conducted by the RAND Southern California Evidence-based Practice Center (SCEPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2012-00006-I). The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

None of the investigators has any affiliations or financial involvement related to the material presented in this report.

The information in this report is intended to help health care decisionmakers—patients and clinicians, health system leaders, and policymakers, among others—make well informed decisions and thereby improve the quality of health care services. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances presented by individual patients.

AHRQ or U.S. Department of Health and Human Services endorsement of any derivative products that may be developed from this report, such as clinical practice guidelines, other quality enhancement tools, or reimbursement or coverage policies may not be stated or implied.

This report may periodically be assessed for currency of conclusions. If an assessment is done, the resulting surveillance report describing the methodology and findings will be found on the Effective Health Care Program Web site at www.effectivehealthcare.ahrq.gov. Search on the title of the report.

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