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Cruickshank M, Henderson L, MacLennan G, et al. Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review. Southampton (UK): NIHR Journals Library; 2016 Mar. (Health Technology Assessment, No. 20.25.)

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Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review.

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Appendix 7Subgroup analyses: primary and secondary outcomes

FIGURE 22. Meta-analysis for mortality according to type of comparator.

FIGURE 22

Meta-analysis for mortality according to type of comparator. Please note that the totals in the forest plot may be subject to minor rounding errors. IV, inverse variance; LORAZ, lorazepam compared with dexmedetomidine; MIDAZOLAM, midazolam compared with dexmedetomidine; PROPOFOL, propofol compared with dexmedetomidine; SC, standard care compared with dexmedetomidine.

FIGURE 23. Meta-analysis for duration of MV according to type of comparator.

FIGURE 23

Meta-analysis for duration of MV according to type of comparator. IV, inverse variance; PROPOFOL, propofol compared with dexmedetomidine; SC, standard care compared with dexmedetomidine.

FIGURE 24. Meta-analysis for ventilator-free days according to type of comparator.

FIGURE 24

Meta-analysis for ventilator-free days according to type of comparator. IV, inverse variance; LORAZ, lorazepam compared with dexmedetomidine; SC, standard care compared with dexmedetomidine.

FIGURE 25. Meta-analysis for length of ICU stay according to type of comparator.

FIGURE 25

Meta-analysis for length of ICU stay according to type of comparator. IV, inverse variance; LORAZ, lorazepam compared with dexmedetomidine; MIDAZOLAM, midazolam compared with dexmedetomidine; PROPOFOL, propofol compared with dexmedetomidine; SC, standard care compared with dexmedetomidine.

FIGURE 26. Meta-analysis for incidence of hypotension according to type of comparator.

FIGURE 26

Meta-analysis for incidence of hypotension according to type of comparator. IV, inverse variance; LORAZ, lorazepam compared with dexmedetomidine; MIDAZOLAM, midazolam compared with dexmedetomidine; SC, standard care compared with dexmedetomidine.

FIGURE 27. Meta-analysis for incidence of hypertension according to type of comparator.

FIGURE 27

Meta-analysis for incidence of hypertension according to type of comparator. Please note that the totals in the forest plot may be subject to minor rounding errors. IV, inverse variance; LORAZ, lorazepam compared with dexmedetomidine; MIDAZOLAM, midazolam compared with dexmedetomidine; PROPOFOL, propofol compared with dexmedetomidine; SC, standard care compared with dexmedetomidine.

FIGURE 28. Meta-analysis for incidence of bradycardia according to type of comparator.

FIGURE 28

Meta-analysis for incidence of bradycardia according to type of comparator. Please note that the totals in the forest plot may be subject to minor rounding errors. IV, inverse variance; LORAZ, lorazepam compared with dexmedetomidine; MIDAZOLAM, midazolam compared with dexmedetomidine; PROPOFOL, propofol compared with dexmedetomidine; SC, standard care compared with dexmedetomidine.

FIGURE 29. Meta-analysis for incidence of delirium according to type of comparator.

FIGURE 29

Meta-analysis for incidence of delirium according to type of comparator. IV, inverse variance; LORAZ, lorazepam compared with dexmedetomidine; MIDAZOLAM, midazolam compared with dexmedetomidine; PROPOFOL, propofol compared with dexmedetomidine; SC, standard care compared with dexmedetomidine.

FIGURE 30. Meta-analysis for self-extubation according to type of comparator.

FIGURE 30

Meta-analysis for self-extubation according to type of comparator. IV, inverse variance; LORAZ, lorazepam compared with dexmedetomidine; MIDAZOLAM, midazolam compared with dexmedetomidine; PROPOFOL, propofol compared with dexmedetomidine; SC, standard care compared with dexmedetomidine.

FIGURE 31. Meta-analysis for incidence of tachycardia according to type of comparator.

FIGURE 31

Meta-analysis for incidence of tachycardia according to type of comparator. IV, inverse variance; LORAZ, lorazepam compared with dexmedetomidine; MIDAZOLAM, midazolam compared with dexmedetomidine; PROPOFOL, propofol compared with dexmedetomidine; SC, standard care compared with dexmedetomidine.

FIGURE 32. Meta-analysis for time in target sedation range according to type of comparator.

FIGURE 32

Meta-analysis for time in target sedation range according to type of comparator. IV, inverse variance; LORAZ, lorazepam compared with dexmedetomidine; MIDAZOLAM, midazolam compared with dexmedetomidine; PROPOFOL, propofol compared with dexmedetomidine; SC, standard care compared with dexmedetomidine.

FIGURE 33. Meta-analysis for time to extubation according to type of comparator.

FIGURE 33

Meta-analysis for time to extubation according to type of comparator. IV, inverse variance; MIDAZOLAM, midazolam compared with dexmedetomidine; PROPOFOL, propofol compared with dexmedetomidine; SC, standard care compared with dexmedetomidine.

Copyright © Queen’s Printer and Controller of HMSO 2016. This work was produced by Cruickshank et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK355230
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