Table 1, Cost Comparison Table for Rivaroxaban - Rivaroxaban (Xarelto)

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Rivaroxaban (Xarelto): Treatment of Venous Thromboembolic Events (Deep Vein Thrombosis [DVT], Pulmonary Embolism [PE]) and Prevention of Recurrent DVT and PE [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Aug.

Rivaroxaban (Xarelto): Treatment of Venous Thromboembolic Events (Deep Vein Thrombosis [DVT], Pulmonary Embolism [PE]) and Prevention of Recurrent DVT and PE [Internet].

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Table 1Cost Comparison Table for Rivaroxaban

Drug/ Comparator	Strength	Dosage Form	Price ($)	Average Daily Use	Average Daily Drug Cost ($)^a	Cost of Treatment Course ($)
rivaroxaban (Xarelto)^b	10 mg 15 mg 20 mg	Tablet	2.8400	15 mg twice daily for 3 weeks, then 20 mg once daily	2.84 to 5.68	3 months: 315 6 months: 571
Low-molecular-weight heparins
dalteparin sodium (Fragmin)	2,500 IU 5,000 IU 7,500 IU 10,000 IU 12,500 IU 15,000 IU 18,000 IU	Syringe	5.2410 10.4810 15.7200 20.9620 26.2020 31.4420 37.7300	200 IU/kg SC daily (not to exceed 18,000 IU daily) for approximately 5 days	31.44	157
enoxaparin sodium (Lovenox)	30 mg 40 mg 60 mg 80 mg 100 mg 150 mg 300 mg	Syringe Syringe Syringe Syringe Syringe Syringe Vial	6.3600 8.4800 12.7200 16.9600 21.2000 31.8000 63.6000	1 mg/kg twice daily for approximately 7 days	33.92	237
nadroparin calcium (Fraxiparine)	9,500 IU/mL 19,000 IU/mL	Syringe	9.1290 18.2580	171 IU/kg SC once daily (not to exceed 17,100 IU daily) for approximately 5 days	18.26	91
tinzaparin sodium (Innohep)	2,500 IU/0.25 mL 3,500 IU/0.35 mL 4,500 IU/0.45 mL 10,000 IU/0.5 mL 14,000 IU/0.7 mL 18,000 IU/0.9 mL	Syringe	4.5000 6.2930 8.0930 18.3740 25.7200 33.0660	175 IU/kg SC daily for approximately 7 days	25.72	180
Other anticoagulants
fondaparinux sodium (Arixtra)	2.5 mg/0.5 mL	Syringe	15.9923	5 mg (body weight < 50 kg), 7.5 mg (50 to 100 kg) or 10 mg (> 100 kg) SC once daily for approximately 7 days	47.98	336
heparin sodium (Heparin Leo)^c	10,000 IU/1 mL 50,000 IU/5 mL	Injection	2.3920 14.3450	17,500 IU SC every 12 hours for 5 days	9.57	48
warfarin (generic)	1 mg 2 mg 2.5 mg 3 mg 4 mg 5 mg 10 mg	Tablet	0.0796 0.0841 0.0674 0.1043 0.1043 0.0675 0.1211	Generally 2 mg to 10 mg daily for at least 6 to 12 months	0.08–0.14	6 months: 15 to 25 12 months: 31 to 49

: IU = international units; SC = subcutaneously.
: Source: Ontario Drug Benefit Formulary (August 2013) unless otherwise stated.
a: Based on a 70 kg patient and assuming wastage of remainder in pre-filled syringe.
b: Manufacturer’s submission.
c: McKesson Canada wholesale pricing (August 2013).
: Note: Treatment with heparin is typically followed by six to 12 months of a vitamin K antagonist (VKA).

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Rivaroxaban (Xarelto): Treatment of Venous Thromboembolic Events (Deep Vein Thrombosis [DVT], Pulmonary Embolism [PE]) and Prevention of Recurrent DVT and PE [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Aug. Table 1, Cost Comparison Table for Rivaroxaban.

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Table 1, Cost Comparison Table for Rivaroxaban - Rivaroxaban (Xarelto)
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