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Chinnadurai S, Snyder K, Sathe N, et al. Diagnosis and Management of Infantile Hemangioma [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016 Jan. (Comparative Effectiveness Reviews, No. 168.)

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Diagnosis and Management of Infantile Hemangioma [Internet].

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Tablet H-6Common Adverse Events Reported in >1% of Patients

Zyclara® 3.75% (n=400)Zyclara® 2.5% (n=379)
Application site pain28 (7.0%)20 (5.3%)
Application site irritation24 (6.0%)13 (3.4%)
Nasopharyngitis16 (4.0%)21 (5.5%)
Upper respiratory tract infection12 (3.0%)7 (1.8%)
Application site pruritus11 (2.8%)17 (4.5%)
Headache9 (2.3%)8 (2.1%)
Vaginitis bacterial8 (2.0%)6 (1.6%)
Nausea7 (1.8%)4 (1.1%)
Back pain7 (1.8%)4 (1.1%)
Urinary tract infection6 (1.5%)6 (1.6%)
Sinusitis6 (1.5%)4 (1.1%)
Sinus congestion6 (1.5%)1 (0.3%)
Cough5 (1.3%)5 (1.3%)
Rash5 (1.3%)2 (0.5%)
Vomiting5 (1.3%)1 (0.3%)
Skin laceration5 (1.3%)1 (0.3%)

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