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Thursz M, Forrest E, Roderick P, et al. The clinical effectiveness and cost-effectiveness of STeroids Or Pentoxifylline for Alcoholic Hepatitis (STOPAH): a 2 × 2 factorial randomised controlled trial. Southampton (UK): NIHR Journals Library; 2015 Dec. (Health Technology Assessment, No. 19.102.)

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The clinical effectiveness and cost-effectiveness of STeroids Or Pentoxifylline for Alcoholic Hepatitis (STOPAH): a 2 × 2 factorial randomised controlled trial.

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Appendix 1Prognostic score formula

Discriminant function

DF=4.6×(prothrombintime(PTPATIENTPTCONTROL)+serumbilirubin(µmol/l)/17.1.
(4)

(PTCONTROL is defined as the mean value at each centre; this mean value may be updated on a weekly or monthly basis.)

TABLE 46

Glasgow Alcoholic Hepatitis Score

Parameter123
Age (years)< 50≥ 50
WBC (× 109)< 15≥ 15
Urea (mmol)< 5≥ 5
Prothrombin ratio< 1.51.5–2.0> 2.0
Bilirubin (µmol)< 125125–250> 250

Lille score

Lillescore=3.190.101×(ageinyears)+0.147×(albuminday0ing/l)+0.0165×(evolutioninbilirubinlevelinµmol)0.206×(renalinsufficiency)0.0065×(bilirubinday0inµm)0.0096×(prothrombintimeinseconds).
(5)

Model for end-stage liver disease score

MELD=9.57×Ln(creatinine)+3.78×Ln(bilirubin)+11.2×Ln(INR)+6.43.
(6)
Copyright © Queen’s Printer and Controller of HMSO 2015. This work was produced by Thursz et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK333626

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