Excerpt

In response to a request of Congress, the National Institutes of Health (NIH) charged the National Academies to critically examine the general desirability and necessity of using random source dogs and cats in NIH-funded research, and the specific necessity of using dogs and cats from Class B dealers for such research.

Contents

• The National Academies
• Committee on Scientific and Humane Issues in the Use of Random Source Dogs and Cats in Research
• Institute for Laboratory Animal Research Council
• Institute for Laboratory Animal Research Publications
• Preface
• Summary
  • BACKGROUND
  • MANDATE AND STATEMENT OF TASK FOR THE REPORT
  • CHARACTERISTICS OF RANDOM SOURCE ANIMALS FOR NIH-FUNDED RESEARCH
  • TRENDS AND STATUS OF CLASS B ANIMALS AND DEALERS
  • GENERAL CONCLUSIONS
  • CONCLUSIONS AND RECOMMENDATIONS
  • IMPACT OF RECOMMENDATIONS
  • CONCLUDING STATEMENT
  • GLOSSARY OF ABBREVIATIONS USED IN THIS REPORT
• 1. Introduction
  • CONGRESSIONAL MANDATE FOR THIS STUDY
  • TIMELINE FOR THIS NRC STUDY
  • ANIMAL WELFARE ACT AND USDA DEFINITIONS
  • OVERVIEW OF EXISTING ANIMAL WELFARE REGULATIONS AND GUIDELINES
  • ANIMAL WELFARE ACT PROVISIONS IN REGARD TO DOGS AND CATS
  • COMMITTEE APPROACH TO ITS CHARGE
  • FOCUS AND ORGANIZATION OF THIS REPORT
  • REFERENCES
• 2. Use of Dogs and Cats in Research: Public Perception and Evolution of Laws and Guidelines
  • PUBLIC PERCEPTIONS OF DOGS AND CATS AND OF THEIR USE IN RESEARCH
  • THE ANIMAL PROTECTION MOVEMENT
  • EVOLUTION OF ANIMAL CARE OVERSIGHT WITHIN THE SCIENTIFIC COMMUNITY
  • EFFECTS OF ANIMAL PROTECTION ACTIVITIES ON CLASS B DEALERS AND ON SCIENTIFIC ACCESS TO RANDOM SOURCE DOGS AND CATS
  • HISTORY OF U.S. LAWS AND GUIDELINES REGARDING THE USE OF DOGS AND CATS IN RESEARCH
  • REFERENCES
• 3. Use of Random Source Dogs and Cats for Research
  • THE “3RS” PRINCIPLE
  • DESIRABILITY OF RANDOM SOURCE DOGS AND CATS FOR RESEARCH
  • RANDOM SOURCE DOGS: ANATOMIC AND PHYSIOLOGIC ATTRIBUTES
  • RANDOM SOURCE CATS: ANATOMIC AND PHYSIOLOGIC ATTRIBUTES
  • IACUC AND PRINCIPAL INVESTIGATOR CONSIDERATIONS REGARDING THE USE OF RANDOM SOURCE ANIMALS FOR RESEARCH
  • DELETERIOUS INFECTIOUS DISEASE ISSUES
  • ZOONOTIC DISEASE HAZARDS AMONG RANDOM SOURCE ANIMALS
  • ADVERSE EFFECTS OF INFECTIOUS DISEASE ON RESEARCH
  • ANIMAL WELFARE ISSUES
  • REFERENCES
• 4. Class B Dealers and Animals
  • TRENDS IN THE NUMBER OF CLASS B DOGS AND CATS USED IN RESEARCH
  • THE ROLE OF CLASS B DEALERS IN PROVIDING RANDOM SOURCE ANIMALS
  • TRENDS IN THE NUMBER OF CLASS B DEALERS
  • SOURCES OF DOGS AND CATS FOR CLASS B DEALERS
  • COST OF ANIMALS FROM CLASS B DEALERS
  • AWA ENFORCEMENT
  • INCONSISTENCIES IN QUALITY AMONG CLASS B DEALERS
  • ALTERNATIVES TO CLASS B ANIMALS
  • UNRESOLVED CLASS B COMPLIANCE ISSUES
  • REFERENCES
• 5. Conclusions and Recommendations
• Appendix Committee Biographies

This study was supported by the National Institutes of Health through Contract Number N-01-OD-4-2139 Task Order #207.

Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of the organizations or agencies that provided support for the project. The content of this publication does not necessarily reflect the views or policies of the National Institutes of Health, nor does mention of trade names, commercial products, or organizations imply endorsement by the US government.

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the Committee responsible for the report were chosen for their special competences and with regard for appropriate balance.