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Brazzelli M, Cruickshank M, Tassie E, et al. Collagenase clostridium histolyticum for the treatment of Dupuytren’s contracture: systematic review and economic evaluation. Southampton (UK): NIHR Journals Library; 2015 Oct. (Health Technology Assessment, No. 19.90.)

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Collagenase clostridium histolyticum for the treatment of Dupuytren’s contracture: systematic review and economic evaluation.

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Appendix 14Sensitivity analyses: replacing missing standard deviation in the meta-analyses assessing change in range of motion and change in contracture

Change in range of motion

FIGURE 40. Change in ROM (SD for Hurst et al.

FIGURE 40

Change in ROM (SD for Hurst et al.55 = 1). IV, inverse variance.

FIGURE 41. Change in ROM (SD for Hurst et al.

FIGURE 41

Change in ROM (SD for Hurst et al.55 = 40). IV, inverse variance.

FIGURE 42. Change in ROM (SD for Hurst et al.

FIGURE 42

Change in ROM (SD for Hurst et al.55 = 60). IV, inverse variance.

FIGURE 43. Change in ROM (SD for Hurst et al.

FIGURE 43

Change in ROM (SD for Hurst et al.55 = 100). IV, inverse variance.

FIGURE 44. Change in ROM (SD for Hurst et al.

FIGURE 44

Change in ROM (SD for Hurst et al.55 = 200). IV, inverse variance.

FIGURE 45. Change in ROM (SD for Hurst et al.

FIGURE 45

Change in ROM (SD for Hurst et al.55 = high collagenase SD, low placebo SD). IV, inverse variance.

FIGURE 46. Change in ROM (SD for Hurst et al.

FIGURE 46

Change in ROM (SD for Hurst et al.55 = low collagenase SD, high placebo SD). IV, inverse variance.

Change in contracture

FIGURE 47. Change in contracture (SD for Hurst et al.

FIGURE 47

Change in contracture (SD for Hurst et al.55 = 1). IV, inverse variance.

FIGURE 48. Change in contracture (SD for Hurst et al.

FIGURE 48

Change in contracture (SD for Hurst et al.55 = 40). IV, inverse variance.

FIGURE 49. Change in contracture (SD for Hurst et al.

FIGURE 49

Change in contracture (SD for Hurst et al.55 = 60). IV, inverse variance.

FIGURE 50. Change in contracture (SD for Hurst et al.

FIGURE 50

Change in contracture (SD for Hurst et al.55 = 100). IV, inverse variance.

FIGURE 51. Change in contracture (SD for Hurst et al.

FIGURE 51

Change in contracture (SD for Hurst et al.55 = 200). IV, inverse variance.

FIGURE 52. Change in contracture (SD for Hurst et al.

FIGURE 52

Change in contracture (SD for Hurst et al.55 = high collagenase SD, low placebo SD). IV, inverse variance.

FIGURE 53. Change in contracture (SD for Hurst et al.

FIGURE 53

Change in contracture (SD for Hurst et al.55 = low collagenase SD, high placebo SD). IV, inverse variance.

Copyright © Queen’s Printer and Controller of HMSO 2015. This work was produced by Brazzelli et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK326591
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