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Brazzelli M, Cruickshank M, Tassie E, et al. Collagenase clostridium histolyticum for the treatment of Dupuytren’s contracture: systematic review and economic evaluation. Southampton (UK): NIHR Journals Library; 2015 Oct. (Health Technology Assessment, No. 19.90.)

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Collagenase clostridium histolyticum for the treatment of Dupuytren’s contracture: systematic review and economic evaluation.

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Appendix 9Risk-of-bias assessment for individual collagenase randomised controlled trials

TABLE 41

Risk-of-bias assessment for individual collagenase RCTs

Domain (type of bias assessed)Badalamente 200264Badalamente 200765Hurst 200955Gilpin 201056
Sequence generation (selection bias)??✓✓
Allocation concealment (selection bias)??✓✓
Blinding of participants (performance bias)✓✓✓✓
Blinding of health-care providers (performance bias)✓✓✓?
Blinding of outcome assessment (detection bias)????
Groups treated identically (performance bias)✓✓✓✓
Incomplete outcome data (attrition bias)?✓✓✓
Intention to treat (attrition bias)✓✓✓✓
Selective reporting (reporting bias)✓✗✓✓
Other bias✗✗✗✗

✓, low risk of bias; ✗, high risk of bias; ?, unclear risk of bias.

Copyright © Queen’s Printer and Controller of HMSO 2015. This work was produced by Brazzelli et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK326576
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