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Qureshi N, Wilson B, Santaguida P, et al. Family History and Improving Health. Rockville (MD): Agency for Healthcare Research and Quality (US); 2009 Aug. (Evidence Reports/Technology Assessments, No. 186.)
This publication is provided for historical reference only and the information may be out of date.
Webtable 17Predictive values associated with FH definitions for diabetes in cross-sectional analyses
| FH category | Specific definition | Age criterion | Lineage criterion | Studies | Disease prevalence in study sample (%) | Prevalence of positive FH in study sample (%) | PPV for study sample | NPV for study sample | Most highly adjusted reported OR or equivalent1 |
|---|---|---|---|---|---|---|---|---|---|
| B | ≥1 parent | N | N | Nyenwe, M&F | 6.9 | 7.7 | 0.26 | 0.95 | 9.4 |
| Annis, M&F | 9.6 | 24.1 | 0.19 | 0.93 | 3.04 (one parent) | ||||
| Carlsson, M&F | 2.1 | 10.4 | 0.05 | 0.98 | 4.622 | ||||
| Mohan, M&F | 12.0 | 19.7 | 0.18 | 0.89 | 2.05 | ||||
| B | father | N | N | Annis, M&F | 9.6 | 10.4 | 0.17 | 0.91 | NR |
| Carlsson, M&F | 2.1 | 4.3 | 0.04 | 0.98 | 4.292 | ||||
| B | mother | N | N | Annis, M&F | 9.6 | 16.2 | 0.22 | 0.93 | NR |
| Carlsson, M&F | 2.1 | 6.6 | 0.06 | 0.98 | 5.172 | ||||
| B | ≥1 sibling | N | N | Annis, M&F | 9.6 | 13.1 | 0.28 | 0.93 | 3.52 |
| Carlsson, M&F | 2.1 | 3.1 | 0.08 | 0.98 | 2.922 | ||||
| B | brother | N | N | Annis, M&F | 9.6 | 7.5 | 0.30 | 0.92 | NR |
| Carlsson, M&F | 2.1 | 2.5 | 0.10 | 0.98 | 4.762 | ||||
| B | sister | N | N | Annis, M&F | 9.6 | 8.2 | 0.31 | 0.92 | NR |
| Carlsson, M&F | 2.1 | 2.2 | 0.10 | 0.98 | 4.012 | ||||
| B | ≥1 child | N | N | Carlsson, M&F | 2.1 | 0.8 | 0.06 | 0.98 | 2.402 |
| B | father or brother | N | N | Carlsson, M&F | 2.1 | 5.7 | 0.05 | 0.98 | 3.582 |
| B | mother or sister | N | N | Carlsson, M&F | 2.1 | 7.5 | 0.06 | 0.98 | 4.162 |
| C | ≥1 1DR | N | N | Carlsson, M&F | 2.1 | 15.2 | 0.06 | 0.99 | 3.512 |
| Bindraban, M&F | 13.7 | 59.9 | 0.19 | 0.94 | 2.7 | ||||
| Shera, M | 9.3 | 11.0 | 0.22 | 0.92 | NR | ||||
| Shera, F | 8.4 | 10.3 | 0.18 | 0.93 | NR | ||||
| C | ≥1 parent or sibling | N | N | Gikas, M&F | 8.7 | 23.3 | 0.24 | 0.96 | 6.91 |
| Annis, M&F | 9.6 | 31.5 | 0.19 | 0.95 | 3.95 | ||||
| Haron, M | 14.9 | 27.0 | 0.18 | 0.86 | 2.53 | ||||
| Haron, F | 10.6 | 29.9 | 0.14 | 0.91 | 2.53 | ||||
| C | ≥2 1DR | N | N | Carlsson, M&F | 2.1 | 1.9 | 0.13 | 0.98 | 8.332 |
| C | ≥2 1DR (parents or sibling) | N | N | Annis, M&F | 9.6 | 8.2 | 0.32 | 0.92 | 5.14 |
| C | ≥3 1DR (parents or sibling) | N | N | Annis, M&F | 9.6 | 2.2 | 0.52 | 0.91 | 14.83 |
| D | ≥1 1DR, aunt or uncle | N | N | Ebbesson, M&F | 6.2 | 19.0 | 0.12 | 0.95 | 4.4 |
| Ebbesson, M | 4.2 | 15.4 | 0.09 | 0.97 | NR | ||||
| Ebbesson, F | 8.8 | 20.0 | 0.17 | 0.93 | NR | ||||
| D | ≥1 1DR or ≥1 2DR | N | N | Ajlouni, M&F | 17.4 | 43.4 | 0.23 | 0.87 | 3.09 |
| D | ≥1 1DR or ≥2 2DR | N | N | Hilding, M | 2.3 | 50.1 | 0.04 | 0.99 | 3.1 |
| Hilding, F | 1.4 | 52.7 | 0.02 | 0.99 | 1.7 | ||||
| E | ≥1 1DR and 1 2DR, same lineage OR 1 1DR OR both parents OR 2 2DR, same lineage | N | Y | Hariri, M&F | 10.4 | 35.8 | 0.21 | 0.96 | 3.6 |
| E | ≥2 1DR, same lineage OR ≥1 1DR and ≥2 2DR, same lineage OR ≥3 2DR same lineage | N | Y | Hariri, M&F | 10.4 | 16.4 | 0.29 | 0.93 | 4.7 |
Abbreviations: 1DR=first degree relative; 2DR=second degree relative; FH=family history; N=no; NPV=negative predictive value; NR=not reported; PPV=positive predictive value; RR=relative risk; y=years; Y=yes
- 1
OR=odds ratio, metric reported unless otherwise stated
- 2
Type 2 diabetes
- 3
Data for males and females combined
- Webtable 17, Predictive values associated with FH definitions for diabetes in cr...Webtable 17, Predictive values associated with FH definitions for diabetes in cross-sectional analyses - Family History and Improving Health
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