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Dretzke J, Blissett D, Dave C, et al. The cost-effectiveness of domiciliary non-invasive ventilation in patients with end-stage chronic obstructive pulmonary disease: a systematic review and economic evaluation. Southampton (UK): NIHR Journals Library; 2015 Oct. (Health Technology Assessment, No. 19.81.)

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The cost-effectiveness of domiciliary non-invasive ventilation in patients with end-stage chronic obstructive pulmonary disease: a systematic review and economic evaluation.

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Chapter 2Aims of the review

Given the remit and the above context, the aims of this report were to undertake:

  1. a systematic review of RCTs and non-RCTs comparing domiciliary NIV with usual care, or different types of NIV, in COPD patients either who are in a stable state of disease (stable population) or who commence NIV immediately after a period of hospitalisation/exacerbation (post-hospital population)
  2. an overview of existing systematic reviews of RCTs comparing domiciliary NIV with usual care, or different types of NIV, in COPD patients
  3. a systematic review of uncontrolled studies (patients on domiciliary NIV only) with the aim of supplementing the findings from the controlled studies where evidence was lacking
  4. a systematic review of the evidence on the cost-effectiveness of domiciliary NIV compared with usual care only in COPD patients
  5. a model-based cost–utility analysis to determine the cost-effectiveness of domiciliary NIV compared with usual care only in COPD patients (stable and post-hospital populations).

Aims 1 to 3 relate to the systematic review of clinical effectiveness and are addressed in Chapters 4 and 5 of this report; aims 4 and 5 relate to the systematic review of cost-effectiveness and the economic model and are addressed in Chapters 6 and 7.

Copyright © Queen’s Printer and Controller of HMSO 2015. This work was produced by Dretzke et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK321590
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