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Foerster V, Perras C, Spry C, et al. Public Health Interventions to Reduce the Secondary Spread of Measles [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 May.

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Public Health Interventions to Reduce the Secondary Spread of Measles [Internet].

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Table 6-2Study Characteristics for Research Question 2 — Immunoglobulin for Susceptible Contacts

Author, YearSheppard et al., 200916
CountryAustralia
Outbreak datesMarch 1 to May 31, 2006
Objective of studyTo assess the effectiveness of MMR vaccine within 3 days of exposure or Ig within 7 days of exposure as PEP during an outbreak
Study designRetrospective cohort study
PopulationNSW residents
DEFINITIONS
   Confirmed caseLaboratory-confirmed case (positive IgM) w/ compatible clinical illness; or virus detection via IF or PCR or culture; or clinical S&S (one or more of fever, cough, coryza, conjunctivitis, and MP rash) w/ link to a laboratory-confirmed case
   Index caseNR
   Secondary caseNR
   ContactAnyone who was in the same room as the case, or the same room for up to 2 hours after the case, during the infectious period
   Susceptible contactInadequate immunity to measles, i.e., age 6 to 12 months; age 1 to 4 years without MMR; age 4 years to adults born after 1996 without 2 MMR doses
   Time to interventionMMR within 3 days of exposure, or Ig within 7 days of exposure
How data were collectedSurveillance officers collected data on S&S of measles cases through interview of cases (or their parents) and their health care providers, and recorded on a standard reporting form. Case interviews were also used to identify possible contacts
InterventionMMR within 3 days of exposure or Ig within 7 days of exposure
Co-interventionInterviews with affected person or carer, including advice about minimizing spread; contact tracing; mass media messages; direct communication to physicians, hospitals, child care centres, and laboratories to raise awareness; extension of eligibility for free MMR vaccine from general practitioners to susceptible persons from May 18, 2006
Outcome (effect measure)Incidence of measles (RR)

IF = immunofluorescence; Ig = immunoglobulin; MMR = measles-mumps-rubella vaccine; MP = maculopapular; NR = not reported; NSW = New South Wales; PCR = polymerase chain reaction; PEP = post-exposure prophylaxis; RR = relative risk; S&S = signs & symptoms; w/ = with.

From: APPENDIX 6, CLINICAL EVIDENCE — STUDY CHARACTERISTICS

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