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Grant MD, Marbella A, Wang AT, et al. Menopausal Symptoms: Comparative Effectiveness of Therapies [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2015 Mar. (Comparative Effectiveness Reviews, No. 147.)
Table N-7Sexual function outcomes by age subgroups
| Trial | Outcome | Subgroup | Treatment | N | Results |
|---|---|---|---|---|---|
| Brunner, 2005, United States | Mean change in satisfaction scorea | Age 50-54 with MSVS | Placebo | 134 | 0.02 (SD: 1.2) |
| 0.625 mg CEE | 140 | -0.07 (SD: 1.1)b | |||
| Hays, 2003, United States | Mean change in satisfaction scorea | Age 50-54 with MSVS | Placebo | 201 | -0.2 (SD: 1.3) |
| 0.625 mg CEE + 2.5 mg MPA | 221 | 0.1 (SD: 1.2)c | |||
| Davis, 2001, Australia | Difference in MENQOL sex score from placebo | Age < 55 | Placebo | NR | - |
| Chinese herbs | NR | -0.72 (95% CI: -2.8 to 1.4) | |||
| Age ≥ 55 | Placebo | NR | - | ||
| Chinese herbs | NR | -0.14 (95% CI: -1.3 to 1.0) | |||
| Rigano, 2001, Italy | Percent reporting decrease in sexual activity | Age 48-50 | Placebo | 75 | 44% |
| 0.05 mg estradiol | 88 | 48% | |||
| Age 51-53 | Placebo | 61 | 62% | ||
| 0.05 mg estradiol | 52 | 75% | |||
| Age 54-56 | Placebo | 55 | 48% | ||
| 0.05 mg estradiol | 31 | 84% | |||
CEE: conjugated equine estrogen; MENQOL: Menopause-specific Quality of Life; MPA: medroxyprogesterone acetate; MSV: moderate to severe vasomotor symptoms; NR: not reported
- a
Satisfaction score from a single question: 1=’very unsatisfied’ to 4=’very satisfied’
- b
difference between groups: p=0.50
- c
difference between groups: p=0.06
- Table N-7, Sexual function outcomes by age subgroups - Menopausal Symptoms: Comp...Table N-7, Sexual function outcomes by age subgroups - Menopausal Symptoms: Comparative Effectiveness of Therapies
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