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Grant MD, Marbella A, Wang AT, et al. Menopausal Symptoms: Comparative Effectiveness of Therapies [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2015 Mar. (Comparative Effectiveness Reviews, No. 147.)
Table N-6Vasomotor outcomes by uterus status subgroups
| Trial | Outcome | Subgroup | Treatment | N | Results |
|---|---|---|---|---|---|
| Hedrick, 2010 Multinational | Mean change in daily MSHFNS | Absent uterus | Placebo | 71 | -5.9 |
| 0.25 mg estradiol | 58 | -8.8a | |||
| 0.50 mg estradiol | 62 | -7.0 | |||
| 1.0 mg estradiol | 68 | -9.7b | |||
| Intact uterus | Placebo | 53 | -4.4 | ||
| 0.25 mg estradiol | 63 | -7.0 | |||
| 0.50 mg estradiol | 57 | -8.0c | |||
| 1.0 mg estradiol | 56 | -8.0c | |||
| Mean change in daily MSHFNS severity score | Absent uterus | Placebo | 71 | -0.5 | |
| 0.25 mg estradiol | 58 | -0.8 | |||
| 0.50 mg estradiol | 62 | -0.8 | |||
| 1.0 mg estradiol | 68 | -1.4c | |||
| Intact uterus | Placebo | 53 | -0.4 | ||
| 0.25 mg estradiol | 63 | -0.9a | |||
| 0.50 mg estradiol | 57 | -1.2c | |||
| 1.0 mg estradiol | 56 | -1.4c | |||
MSHFNS: moderate-to-severe hot flashes and night sweats; N: number
- a
difference from placebo: p<0.05
- b
difference from placebo: p<0.001
- c
difference from placebo: p<0.01
- Table N-6, Vasomotor outcomes by uterus status subgroups - Menopausal Symptoms: ...Table N-6, Vasomotor outcomes by uterus status subgroups - Menopausal Symptoms: Comparative Effectiveness of Therapies
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