SMART Vaccines – Strategic Multi-Attribute Ranking Tool for Vaccines – is a prioritization software tool developed by the Institute of Medicine that utilizes decision science and modeling to help inform choices among candidates for new vaccine development. A blueprint for this computer-based guide was presented in the 2012 report Ranking Vaccines: A Prioritization Framework: Phase I . The 2013 Phase II report refined a beta version of the model developed in the Phase I report.

Ranking Vaccines: Applications of a Prioritization Software Tool: Phase III: Use Case Studies and Data Framework extends this project by demonstrating the practical applications of SMART Vaccines through use case scenarios in partnership with the Public Health Agency of Canada, New York State Department of Health, and the Serum Institute of India. This report also explores a novel application of SMART Vaccines in determining new vaccine product profiles, and offers practical strategies for data synthesis and estimation to encourage the broader use of the software.

Contents

• THE NATIONAL ACADEMIES
• Committee on Identifying and Prioritizing New Preventive Vaccines for Development, Phase III
• Reviewers
• Preface
• Disclaimer
• Summary
  • The Foundational Work on SMART Vaccines
  • Potential Applications of SMART Vaccines
  • Enhancement of SMART Vaccines
  • User Groups and Use Case Scenarios
  • Lessons from the User Group Studies
  • Data Framework
  • Guiding Principles for Enhancing the Value of SMART Vaccines
  • A Sense of Focus and Urgency
• 1. Introduction: SMART Vaccines and Smart Priorities
  • Project Context and Scope
  • Project Process and Stakeholders' Feedback
  • Use Case Scenarios and Data Synthesis
• 2. Data Synthesis and Framework
  • Data Requirements
  • Attributes and Boundary Setting
  • Current Algorithms for Setting Boundaries
  • Considerations for Modifying Boundaries
  • Data Framework
• 3. Use Case Scenarios and Design Enhancements
  • User Group Scenarios
  • Data Sourcing Guidance to the User Groups
  • Updated Features in SMART Vaccines 1.1
  • Two Aspects of SMART Scores
  • Key Insights from the User Groups
  • Fourth Use Case Scenario: Product Profile Design
• 4. Reflections and Looking Forward
  • Transition Paths
  • Ensuring the Growth and Value of SMART Vaccines
  • An Active User Network
  • Outreach and Awareness Enhancement
  • Data Development: An Opportunity Awaiting
  • A Web-Based Platform
  • Intellectual Property Considerations
  • Future Improvements and Research
  • Expanded Uses of SMART Vaccines
  • Overcoming Barriers to Change
• References
• APPENDIXES
  • A Use Case Scenarios Report for SMART Vaccines
  • B Committee's Response to the Use Case Scenarios Report
  • C SMART Vaccines Software Updates
  • D Stakeholder Speakers
  • E Biographical Information

This study was supported in part by Contract No. HHSN275200900087U between the National Academy of Sciences and the Fogarty International Center of the National Institutes of Health, in collaboration with the National Vaccine Program Office of the U.S. Department of Health and Human Services. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project.

Suggested citation:

Institute of Medicine and National Academy of Engineering. 2015. Ranking vaccines: Applications of a prioritization software tool: Phase III: Use case studies and data framework. Washington, DC: The National Academies Press.

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.