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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
%3B%20b.%20t-BuOK%2C%20t-BuOH%2C%2075%B0C%2C%20overnight%20(84%25)%3B%20c.%20POCl3%2C%2090%B0C%2C%20overnight%20(61%25)%3B%20d.%203-(Piperidin-1-yl)propan-1-amine%2C%20t-BuOK%2010%25%2C%20Dry%20DMA%2C%20135%B0C%2C%20overnight%2C%20nitrogen%20atmosphere%20(57%25).&p=BOOKS&id=280042_ml400f4.jpg "Click on image to zoom")
Scheme 1Synthesis of ML400, conditions: a. 4-Methoxybenzoyl chloride, DIPEA, DCM, 0°C to RT, overnight (80%); b. t-BuOK, t-BuOH, 75°C, overnight (84%); c. POCl3, 90°C, overnight (61%); d. 3-(Piperidin-1-yl)propan-1-amine, t-BuOK 10%, Dry DMA, 135°C, overnight, nitrogen atmosphere (57%)
(Scheme 1)
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- Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.[J Pathol. 2015]Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.Wade F, Quijada P, Al-Haffar KM, Awad SM, Kunhi M, Toko H, Marashly Q, Belhaj K, Zahid I, Al-Mohanna F, et al. J Pathol. 2015 Dec; 237(4):482-94. Epub 2015 Sep 1.
- Review Protein tyrosine phosphatase 1B as a target for the treatment of impaired glucose tolerance and type II diabetes.[Curr Opin Investig Drugs. 2002]Review Protein tyrosine phosphatase 1B as a target for the treatment of impaired glucose tolerance and type II diabetes.Liu G, Trevillyan JM. Curr Opin Investig Drugs. 2002 Nov; 3(11):1608-16.
- Review Protein tyrosine phosphatases: the quest for negative regulators of insulin action.[Am J Physiol Endocrinol Metab....]Review Protein tyrosine phosphatases: the quest for negative regulators of insulin action.Asante-Appiah E, Kennedy BP. Am J Physiol Endocrinol Metab. 2003 Apr; 284(4):E663-70.
- Scheme 1, Synthesis of ML400, conditions: a. 4-Methoxybenzoyl chloride, DIPEA, D...Scheme 1, Synthesis of ML400, conditions: a. 4-Methoxybenzoyl chloride, DIPEA, DCM, 0°C to RT, overnight (80%); b. t-BuOK, t-BuOH, 75°C, overnight (84%); c. POCl3, 90°C, overnight (61%); d. 3-(Piperidin-1-yl)propan-1-amine, t-BuOK 10%, Dry DMA, 135°C, overnight, nitrogen atmosphere (57%) - Probe Reports from the NIH Molecular Libraries Program
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