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Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.

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Table 19.

Advantages and Disadvantages of SGLT2 Inhibitors

AdvantagesDisadvantages
Weight lossUrinary Tract Infections?
No hypoglycemiaGenital Mycotic Infections
Decrease heart failureIncreased LDL (small increase)
Decreases renal diseaseIncreased risk of DKA
Once a day administrationPostural hypotension/volume depletion
Decrease BPFractures/ Osteoporosis?
Increased risk amputations (canagliflozin)?
Fournier’s gangrene (rare)?
Expensive

From: Oral and Injectable (Non-Insulin) Pharmacological Agents for the Treatment of Type 2 Diabetes

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