An official website of the United States government
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
Mechanism of aldosterone action on sodium reabsorption at the distal convoluted tubule of the nephron. Aldosterone binds to the MR, which is located in the cytoplasm in complex with heat shock proteins 90, 70 and 50. After binding, the receptor-ligand complex translocates into the nucleus, binds to hormone-responsive elements (HRE) of target genes where it modulates their transcription rate. Amiloride-sensitive sodium channel (ENaC) subunits or other related proteins may be targets of such regulation (40).
From: Aldosterone Deficiency and Resistance
This electronic version has been made freely available under a Creative Commons (CC-BY-NC-ND) license. A copy of the license can be viewed at http://creativecommons.org/licenses/by-nc-nd/2.0/.
Your browsing activity is empty.
Activity recording is turned off.
See more...
