Figure 13-63. Model of lipid rafts in the trans Golgi network.

Figure 13-63Model of lipid rafts in the trans Golgi network

Glycosphingolipids and cholesterol are thought to form rafts in the lipid bilayer. Membrane proteins with long enough membrane-spanning segments preferentially partition into the lipid rafts and thus become sorted into transport vesicles. These rafts are subsequently packaged into transport vesicles that carry them to the apical domain of the plasma membrane. Carbohydrate-binding proteins (lectins) in the lumen of the trans Golgi network may help stabilize the rafts, as shown.

From: Transport from the Trans Golgi Network to the Cell Exterior: Exocytosis

Cover of Molecular Biology of the Cell
Molecular Biology of the Cell. 4th edition.
Alberts B, Johnson A, Lewis J, et al.
New York: Garland Science; 2002.
Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .

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