Figure 13-55. The three best-understood pathways of protein sorting in the trans Golgi network.

Figure 13-55The three best-understood pathways of protein sorting in the trans Golgi network

(1) Proteins with the mannose 6-phosphate (M6P) marker are diverted to lysosomes (via late endosomes) in clathrin-coated transport vesicles (see Figure 13-37). (2) Proteins with signals directing them to secretory vesicles are concentrated in such vesicles as part of a regulated secretory pathway that is present only in specialized secretory cells. (3) In unpolarized cells, proteins with no special features are delivered to the cell surface by a constitutive secretory pathway. In polarized cells, however, secreted and plasma membrane proteins are selectively directed to either the apical or the basolateral plasma membrane domain, so that at least one of these two pathways must be mediated by a specific signal, as we discuss later.

Image ch13f37

From: Transport from the Trans Golgi Network to the Cell Exterior: Exocytosis

Cover of Molecular Biology of the Cell
Molecular Biology of the Cell. 4th edition.
Alberts B, Johnson A, Lewis J, et al.
New York: Garland Science; 2002.
Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .

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