Figure 1, Ratios related to the minimum inhibitory concentration of the organisms - Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic Treatment for Hospital-Acquired Pneumonia

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Lux LJ, Posey RE, Daniels LS, et al. Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic Treatment for Hospital-Acquired Pneumonia [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 Nov. (Comparative Effectiveness Reviews, No. 136.)

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Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic Treatment for Hospital-Acquired Pneumonia [Internet].

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Figure 1 is titled “Ratios to the MIC of the organisms.” The figure displays a graph of antibiotic serum concentration (the y-axis, labeled “Concentration”) as a function of time (the x-axis, labeled “Time”). The graph shows the minimum inhibitory concentration for an organism (represented as a horizontal line labeled MIC), the time above the minimum inhibitory concentration (represented as the distance between the point at which the serum concentration function rises above the minimum inhibitory concentration line and the point at which it drops below the minimum inhibitory concentration line, labeled T>MIC), the maximum serum concentration needed to inhibit microorganisms (represented as the peak of the serum concentration function, labeled Cmax), the ratio of maximum serum concetration (or peak) to the time above the minimum inhibitory concentration needed to inhibit microorgansims (represented as a bar showing the distance between the minimum inhibitory concentration line and the maximum serum concentration point, labeled Cmax/MIC), and the ratio of the antibiotic area under the curve to the time above the minimum inhibitory concentration (represented as the shaded area in which the serum concentration function is above the minimum inhibitory concentration line, labeled AUC/MIC).

Figure 1Ratios related to the minimum inhibitory concentration of the organisms

AUC = antibiotic area under the curve; AUC/MIC = the ratio of the antibiotic area under the curve to the time above the minimum inhibitory concentration needed to inhibit microorganisms; C_max = the maximum serum concentration needed to inhibit microorganisms; C_max/MIC = ratio of maximum serum concentration (or peak) to the time above the minimum inhibitory concentration needed to inhibit microorganisms; MIC = minimal inhibitory concentration; T = time.

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Lux LJ, Posey RE, Daniels LS, et al. Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic Treatment for Hospital-Acquired Pneumonia [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 Nov. (Comparative Effectiveness Reviews, No. 136.) Figure 1, Ratios related to the minimum inhibitory concentration of the organisms.
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