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Mowatt G, Hernández R, Castillo M, et al. Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation. Southampton (UK): NIHR Journals Library; 2014 Dec. (Health Technology Assessment, No. 18.69.)

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Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation.

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Appendix 7Studies reporting eye-related exclusion criteria

TABLE 48

Diagnostic studies

StudyEye-related exclusion criteria
Alster 200524
  • Presence of any significant media opacity that precludes a clear view of the fundus on fundus photography and FFA
  • Any non-macular-related ocular surgery performed within 3 months before the study
Cachulo 201125
  • Current or past history of an ophthalmic disease in the study eye (other than AMD) that would likely compromise the VA of the study eye
  • Clinical signs of myopic retinopathy or refractive power > 8 diopters or fundoscopic evidence of degenerative myopia
  • Past history of intraocular surgery within 60 days prior to enrolling in the study
  • Evidence of past or present CNV in the study eye
Do 201227
  • Evidence of CNV or foveal geographic atrophy in the fellow (candidate study) eye
Gomi 200731
  • Subretinal or subpigment epithelial haemorrhages that obscured lesions
  • History of any previous treatment and any other macular pathologies such as CNV or central serous chorioretinopathy
Loewenstein 201039
  • Macular disease other than AMD
  • Geographic atrophy
  • Media opacity precluding a clear view of the fundus
  • Ocular surgery in the study eye with in the previous 3 months
Padnick-Silver 201240
  • Presence of other retinal disease in the eye with non-nAMD (e.g. significant diabetic retinopathy, glaucomatous retinal atrophy, retinal detachment)
Park 201041
  • RAP or concurrent macular haemorrhage that might obscure part of the CNVM on FFA
Reichel 199544
  • Previous laser photocoagulation in the study eye
Sulzbacher 201148
  • Neovascular maculopathy from pathologic myopia, angioid streaks, infectious inflammatory chorioretinal disease, tumours, hereditary disorders, or trauma
Talks 200749
  • Macular holes
  • Central serous retinopathy
  • Disciform scar

TABLE 49

Monitoring studies

StudyEye-related exclusion criteria
Giani 201130
  • Any previous laser treatment, PDT, or vitreoretinal surgery on the study eye
  • Significant macular haemorrhage that obscured the lesion
  • Spherical refractive error > 6 diopters
Khurana 201023
  • CNV resulting from other causes
Copyright © Queen’s Printer and Controller of HMSO 2014. This work was produced by Mowatt et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK263931
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