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Grant AM, Boachie C, Cotton SC, et al. Clinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease: 5-year follow-up of multicentre randomised trial (the REFLUX trial). Southampton (UK): NIHR Journals Library; 2013 Jun. (Health Technology Assessment, No. 17.22.)

Cover of Clinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease: 5-year follow-up of multicentre randomised trial (the REFLUX trial)

Clinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease: 5-year follow-up of multicentre randomised trial (the REFLUX trial).

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TABLE 36

Comparison between the complete-case and multiple imputation data sets for costs and HRQoL, according to ITT allocation

YearIncremental mean cost (cost surgery - cost medical management) (95% CIa) (£)Difference in mean EQ-5D (surgery - medical management) (95% CIa)
Complete caseMultiple imputationFollow-upComplete caseMultiple imputation
N/AN/AN/ABaseline−0.0388 (−0.1083 to 0.0308)−0.0091 (−0.0615 to 0.0433)
N/AN/AN/A3 months0.0848 (0.0122 to 0.1573)0.0825 (0.0232 to 0.0142)
12197.14 (1779.67 to 2614.61)1958.46 (1617.31 to 2299.62)Year 10.0519 (−0.0198 to 0.1237)0.0407 (−0.0150 to 0.0963)
2−139.14 (−237.02 to −41.26)−44.58 (−129.68 to 40.52)Year 20.0467 (−0.0356 to 0.1289)0.0445 (−0.0218 to 0.1108)
3−193.44 (−361.94 to −24.93)−127.42 (−306.36 to 51.52)Year 30.0508 (−0.0195 to 0.1211)0.0454 (−0.0150 to 0.1057)
4−37.66 (−173.02 to 97.70)−144.61 (−374.78 to 85.56)Year 40.0324 (−0.0395 to 0.1044)0.0260 (−0.0356 to 0.0875)
5−165.12 (−304.74 to −25.50)−123.90 (−236.56 to −11.24)Year 5−0.0095 (−0.0871 to 0.0680)0.0294 (−0.0358 to 0.0945)
Total cost1661.78 (1130.00 to 2193.55)1517.95 (1006.49 to 2029.41)Total QALYs (unadjusted)0.1976 (−0.0857 to 0.4810)0.1948 (−0.0356 to 0.4251)
Monte Carlo errorb10.16Monte Carlo errorb0.0034
Total QALYs (adjusted)c0.3039 (0.0928 to 0.5150)0.2160 (0.0205 to 0.4115)
Monte Carlo errorb0.0035

N/A, not applicable (due to costs being calculated using the area under the curve method).

a

95% CI estimated with OLS regression and the ‘mim’ command.

b

Monte Carlo error – SD across repeated runs of the same imputation procedure with the same data.69

c

Total QALYs adjusted for baseline EQ-5D.

From: Chapter 5, Economic analysis

Copyright © Queen's Printer and Controller of HMSO 2013. This work was produced by Grant et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

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