- SMN Modulator ML372 Increases SMN Protein Abundance, Body Weight, Lifespan, and Rescues Motor Function in SMNΔ7 SMA Mice
- Development of the First Potent, Selective and CNS penetrant M5 Negative Allosteric Modulator (NAM)
- Inhibitors of Myocyte Triacylglyceride Accumulation
- An in Vivo Active Carbamate-based Dual Inhibitor of Lysophospholipase 1 (LYPLA1) and Lysophospholipase 2 (LYPLA2)
- A Candidate Cell-Selective Anticancer Agent
- Development of the First CNS penetrant M5 Positive Allosteric Modulator (PAM) Based on a Novel, non-Isatin Core
- Development of a Novel, Orthosteric M5 Antagonist Possessing a High Degree of Muscarinic Subtype Selectivity
- Discovery and characterization of a small molecule allosteric agonist of MrgX1
- Discovery of two small molecule inhibitors, ML387 and ML388, of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
- Optimization and characterization of an antagonist for vasopressin 1a (V1a) receptor
- Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia
- Inhibitors of the Plasmodium falciparum M17 Leucine Aminopeptidase
- A Next generation PLD2 inhibitor with improved physiochemical properties and DMPK profile for translational in vivo
- The discovery and characterization of a centrally penetrant (ML396) and a peripherally restricted (ML397) pan-Group III mGlu positive allosteric modulators
- Discovery and characterization of ML398, a potent and selective chiral morpholine based antagonist of the dopamine 4 (D4) receptor
- Progress towards small molecule inhibitors of the Menin-Mixed Lineage Leukemia (MLL) interaction with in vivo utility
- Allosteric Small Molecule Inhibitors of LMPTP
- Functional Antagonists of EBI-2
- Small Molecules Targeting the Mitochondrial Permeability Transition
- Discovery of small molecule probe that shows anti-tubercular activity via Mtb bioA (DAPA synthase) enzyme inhibition
- Discovery and Evaluation of Fungicidal Anti-Cryptococcal Molecules
- Identification of a chemically validated target in replicating and non-replicating Mycobacterium tuberculosis with the aid of a small molecule probe
Publication Details
Copyright
Publisher
National Center for Biotechnology Information (US), Bethesda (MD)
NLM Citation
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Year 6 Reports.